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• W2586368049 startingPage "1" @default.
• W2586368049 abstract "Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is a curative treatment option for both malignant and some benign hematological diseases. During the last decade, many of the newer high-dose regimens in different intensity have been developed specifically for patients with hematologic malignancies and solid tumors. Today there are three main approaches used prior to allogeneic transplantation: Myeloablative (MA), Reduced Intensity Conditioning (RIC) and Non-MA (NMA) regimens. MA regimens cause irreversible cytopenia and there is a requirement for stem cell support. Patients who receive NMA regimen have minimal cytopenia and this type of regimen can be given without stem cell support. RIC regimens do not fit the criteria of MA and NMA: the cytopenia is reversible and the stem cell support is necessary. NMA/RIC for Allo-HSCT has opened a new era for treating elderly patients and those with comorbidities. The RIC conditioning was used for 40% of all Allo-HSCT and this trend continue to increase. In this paper, we will review these regimens in the setting of especially allogeneic HSCT and our aim is to describe the history, features and impact of these conditioning regimens on specific diseases." @default.
• W2586368049 created "2017-02-17" @default.
• W2586368049 creator A5057599279 @default.
• W2586368049 creator A5081218567 @default.
• W2586368049 date "2017-01-15" @default.
• W2586368049 modified "2023-10-18" @default.
• W2586368049 title "A Review of Myeloablative vs Reduced Intensity/Non-Myeloablative Regimens in Allogeneic Hematopoietic Stem Cell Transplantations" @default.
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• W2586368049 doi "https://doi.org/10.4274/balkanmedj.2017.0055" @default.
• W2586368049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5322516" @default.
• W2586368049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28251017" @default.
• W2586368049 hasPublicationYear "2017" @default.
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