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• W2586542068 abstract "Nigella sativa and its derivatives have been reported to have anti-inflammatory and bronchodilator effects, but the effects have been evaluated in only a few clinical studies.To determine the effect of N sativa supplementation on inflammation of the airways and limitation of airflow in partly controlled asthma patients.Single-blind, placebo-controlled, randomized study.Asthma and allergy clinic of a university hospital in eastern Saudi Arabia.Patients were divided into three groups. A control group (n=24) received the placebo, while NS-1 and NS-2 groups (n=26 each) received 1 and 2 g/day of N sativa, respectively, for 3 months along with maintenance inhaled therapy.Asthma control test (ACT) score, fractional exhaled nitric oxide (FeNO), peak expiratory flow (PEF) variability and other pulmonary function tests, IgE, serum cytokines, and frequency of exacerbations.FEF25-75% and FEV1 (% predicted) increased significantly (P < .05) at both 6 and 12 weeks in the NS-2 group. PEF variability significantly improved in both NS-1 and NS-2 groups at 6 and 12 weeks as compared with the controls (P < .05). FeNO and serum IgE decreased significantly after 12 weeks in both the NS-1 and NS-2 groups vs baseline (P < .05). Both doses of N sativa produced a significant increase in the serum IFN-gamma at 12 weeks vs baseline (P < .05) as well as a significant improvement in the ACT score at 6 and 12 weeks vs baseline (P < .001, < .01). Significantly fewer patients had exacerbations in the NS-1 group (P < .05).N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.No bronchoalveolar lavage or sputum samples taken for measurement of asthma markers. ISRCTN registry: ISRCTN48853858 DOI 10.1186/ISRCTN48853858." @default.
• W2586542068 created "2017-02-17" @default.
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• W2586542068 date "2017-01-01" @default.
• W2586542068 modified "2023-10-14" @default.
• W2586542068 title "Effect of <i>Nigella sativa</i> supplementation on lung function and inflammatory mediators in partly controlled asthma: a randomized controlled trial" @default.
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• W2586542068 doi "https://doi.org/10.5144/0256-4947.2017.64" @default.
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