FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586550166> ?p ?o ?g. }

• W2586550166 endingPage "e0171840" @default.
• W2586550166 startingPage "e0171840" @default.
• W2586550166 abstract "Dihydroartemisinin (DHA) and artesunate (ARS), two artemisinin derivatives, have efficacious anticancer activities against human hepatocarcinoma (HCC) cells. This study aims to study the anticancer action of the combination treatment of DHA/ARS and farnesylthiosalicylic acid (FTS), a Ras inhibitor, in HCC cells (Huh-7 and HepG2 cell lines). FTS pretreatment significantly enhanced DHA/ARS-induced phosphatidylserine (PS) externalization, Bak/Bax activation, mitochondrial membrane depolarization, cytochrome c release, and caspase-8 and -9 activations, characteristics of the extrinsic and intrinsic apoptosis. Pretreatment with Z-IETD-FMK (caspase-8 inhibitor) potently prevented the cytotoxicity of the combination treatment of DHA/ARS and FTS, and pretreatment with Z-VAD-FMK (pan-caspase inhibitor) significantly inhibited the loss of ΔΨm induced by DHA/ARS treatment or the combination treatment of DHA/ARS and FTS in HCC cells. Furthermore, silencing Bak/Bax modestly but significantly inhibited the cytotoxicity of the combination treatment of DHA/ARS and FTS. Interestingly, pretreatment with an antioxidant N-Acetyle-Cysteine (NAC) significantly prevented the cytotoxicity of the combination treatment of DHA and FTS instead of the combination treatment of ARS and FTS, suggesting that reactive oxygen species (ROS) played a key role in the anticancer action of the combination treatment of DHA and FTS. Similar to FTS, DHA/ARS also significantly prevented Ras activation. Collectively, our data demonstrate that FTS potently sensitizes Huh-7 and HepG2 cells to artemisinin derivatives via accelerating the extrinsic and intrinsic apoptotic pathways." @default.
• W2586550166 created "2017-02-17" @default.
• W2586550166 creator A5000460202 @default.
• W2586550166 creator A5003091821 @default.
• W2586550166 creator A5015286945 @default.
• W2586550166 creator A5061682647 @default.
• W2586550166 creator A5078330016 @default.
• W2586550166 creator A5085345865 @default.
• W2586550166 creator A5089812226 @default.
• W2586550166 date "2017-02-09" @default.
• W2586550166 modified "2023-09-24" @default.
• W2586550166 title "Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives" @default.
• W2586550166 cites W1525183361 @default.
• W2586550166 cites W1546326655 @default.
• W2586550166 cites W1583472519 @default.
• W2586550166 cites W1752845679 @default.
• W2586550166 cites W1786558351 @default.
• W2586550166 cites W1827917779 @default.
• W2586550166 cites W1918647939 @default.
• W2586550166 cites W1964470200 @default.
• W2586550166 cites W1964483580 @default.
• W2586550166 cites W1966091165 @default.
• W2586550166 cites W1967596683 @default.
• W2586550166 cites W1975195678 @default.
• W2586550166 cites W1976046338 @default.
• W2586550166 cites W1976214899 @default.
• W2586550166 cites W1986974715 @default.
• W2586550166 cites W1993718313 @default.
• W2586550166 cites W1995773170 @default.
• W2586550166 cites W1995958446 @default.
• W2586550166 cites W1997233622 @default.
• W2586550166 cites W1999103364 @default.
• W2586550166 cites W1999703394 @default.
• W2586550166 cites W2007688166 @default.
• W2586550166 cites W2011123905 @default.
• W2586550166 cites W2015523279 @default.
• W2586550166 cites W2018053695 @default.
• W2586550166 cites W2019961689 @default.
• W2586550166 cites W2025778935 @default.
• W2586550166 cites W2026556401 @default.
• W2586550166 cites W2029855707 @default.
• W2586550166 cites W2033992955 @default.
• W2586550166 cites W2038786730 @default.
• W2586550166 cites W2039035641 @default.
• W2586550166 cites W2041586758 @default.
• W2586550166 cites W2042901183 @default.
• W2586550166 cites W2042949990 @default.
• W2586550166 cites W2047722636 @default.
• W2586550166 cites W2048116131 @default.
• W2586550166 cites W2049454907 @default.
• W2586550166 cites W2050853222 @default.
• W2586550166 cites W2053090940 @default.
• W2586550166 cites W2060932390 @default.
• W2586550166 cites W2063625327 @default.
• W2586550166 cites W2067224679 @default.
• W2586550166 cites W2071007484 @default.
• W2586550166 cites W2071492104 @default.
• W2586550166 cites W2074285323 @default.
• W2586550166 cites W2090474971 @default.
• W2586550166 cites W2090875588 @default.
• W2586550166 cites W2096421324 @default.
• W2586550166 cites W2101301592 @default.
• W2586550166 cites W2103562758 @default.
• W2586550166 cites W2104804163 @default.
• W2586550166 cites W2112877031 @default.
• W2586550166 cites W2114031539 @default.
• W2586550166 cites W2119028586 @default.
• W2586550166 cites W2123251409 @default.
• W2586550166 cites W2125405314 @default.
• W2586550166 cites W2126102393 @default.
• W2586550166 cites W2127009195 @default.
• W2586550166 cites W2131661896 @default.
• W2586550166 cites W2133228280 @default.
• W2586550166 cites W2139594142 @default.
• W2586550166 cites W2144951893 @default.
• W2586550166 cites W2144961165 @default.
• W2586550166 cites W2151305493 @default.
• W2586550166 cites W2163827556 @default.
• W2586550166 cites W2220780515 @default.
• W2586550166 cites W2255952763 @default.
• W2586550166 cites W2322386893 @default.
• W2586550166 cites W2336584006 @default.
• W2586550166 cites W2405198949 @default.
• W2586550166 cites W2423132718 @default.
• W2586550166 cites W801576820 @default.
• W2586550166 doi "https://doi.org/10.1371/journal.pone.0171840" @default.
• W2586550166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5300221" @default.
• W2586550166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28182780" @default.
• W2586550166 hasPublicationYear "2017" @default.
• W2586550166 type Work @default.
• W2586550166 sameAs 2586550166 @default.
• W2586550166 citedByCount "8" @default.
• W2586550166 countsByYear W25865501662018 @default.
• W2586550166 countsByYear W25865501662019 @default.
• W2586550166 countsByYear W25865501662021 @default.
• W2586550166 countsByYear W25865501662022 @default.
• W2586550166 countsByYear W25865501662023 @default.
• W2586550166 crossrefType "journal-article" @default.

• next