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- W2586581179 abstract "Abstract The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we investigated the role of HCA2 in macrophage-mediated inflammation and the underlying mechanisms. We found that proinflammatory stimulants LPS, IL-6 and IL-1β up-regulated the expression of HCA2 on macrophages. Niacin significantly inhibited macrophage chemotaxis in response to chemoattractants fMLF and CCL2 by disrupting polarized distribution of F-actin and Gβ protein. Niacin showed a selected additive effect on chemoattractant-induced activation of ERK1/2, JNK and PI3K pathways, but only the MEK inhibitor UO126 reduced niacin-mediated inhibition of macrophage chemotaxis, while activation of ERK1/2 by EGF alone did not inhibit fMLF-mediated migration of HEK293T cells co-expressing HCA2 and fMLF receptor FPR1. In addition, niacin induced heterologous desensitization and internalization of FPR1. Furthermore, niacin rescued mice from septic shock by diminishing inflammatory symptoms and the effect was abrogated in HCA2 −/− mice. These results suggest that Gβγ/PKC-dependent ERK1/2 activation and heterologous desensitization of chemoattractant receptors are involved in the inhibition of chemoattractant-induced migration of macrophages by niacin. Thus, HCA2 plays a critical role in host protection against pro-inflammatory insults." @default.
- W2586581179 created "2017-02-17" @default.
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- W2586581179 date "2017-02-10" @default.
- W2586581179 modified "2023-09-25" @default.
- W2586581179 title "Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization" @default.
- W2586581179 cites W1517012554 @default.
- W2586581179 cites W1947192628 @default.
- W2586581179 cites W1971002603 @default.
- W2586581179 cites W1972403093 @default.
- W2586581179 cites W1974633668 @default.
- W2586581179 cites W1976002518 @default.
- W2586581179 cites W1976310120 @default.
- W2586581179 cites W1981266729 @default.
- W2586581179 cites W1996819821 @default.
- W2586581179 cites W2001099960 @default.
- W2586581179 cites W2003716569 @default.
- W2586581179 cites W2004243328 @default.
- W2586581179 cites W2004536682 @default.
- W2586581179 cites W2004798972 @default.
- W2586581179 cites W2007897263 @default.
- W2586581179 cites W2013853691 @default.
- W2586581179 cites W2014639438 @default.
- W2586581179 cites W2015708524 @default.
- W2586581179 cites W2020647227 @default.
- W2586581179 cites W2026027356 @default.
- W2586581179 cites W2027182286 @default.
- W2586581179 cites W2037717990 @default.
- W2586581179 cites W2038678974 @default.
- W2586581179 cites W2040196938 @default.
- W2586581179 cites W2044192972 @default.
- W2586581179 cites W2046991199 @default.
- W2586581179 cites W2048760313 @default.
- W2586581179 cites W2052554962 @default.
- W2586581179 cites W2056000786 @default.
- W2586581179 cites W2056195685 @default.
- W2586581179 cites W205761956 @default.
- W2586581179 cites W2057634020 @default.
- W2586581179 cites W2058355050 @default.
- W2586581179 cites W2060630008 @default.
- W2586581179 cites W2062208537 @default.
- W2586581179 cites W2069021263 @default.
- W2586581179 cites W2071741407 @default.
- W2586581179 cites W2073659227 @default.
- W2586581179 cites W2073860070 @default.
- W2586581179 cites W2078578691 @default.
- W2586581179 cites W2082161189 @default.
- W2586581179 cites W2084330790 @default.
- W2586581179 cites W2088894802 @default.
- W2586581179 cites W2089505657 @default.
- W2586581179 cites W2089648098 @default.
- W2586581179 cites W2090600090 @default.
- W2586581179 cites W2090765541 @default.
- W2586581179 cites W2091236108 @default.
- W2586581179 cites W2098719212 @default.
- W2586581179 cites W2107751591 @default.
- W2586581179 cites W2119258086 @default.
- W2586581179 cites W2119328183 @default.
- W2586581179 cites W2128353925 @default.
- W2586581179 cites W2128411304 @default.
- W2586581179 cites W2131455671 @default.
- W2586581179 cites W2135566012 @default.
- W2586581179 cites W2137225377 @default.
- W2586581179 cites W2143158290 @default.
- W2586581179 cites W2143544378 @default.
- W2586581179 cites W2144181069 @default.
- W2586581179 cites W2147181044 @default.
- W2586581179 cites W2148928213 @default.
- W2586581179 cites W2157470220 @default.
- W2586581179 cites W2158025896 @default.
- W2586581179 cites W2159913536 @default.
- W2586581179 cites W2160646818 @default.
- W2586581179 cites W2163352150 @default.
- W2586581179 cites W2167145970 @default.
- W2586581179 cites W2168443670 @default.
- W2586581179 cites W2169033201 @default.
- W2586581179 cites W2187593761 @default.
- W2586581179 cites W2254553501 @default.
- W2586581179 cites W4233165110 @default.
- W2586581179 doi "https://doi.org/10.1038/srep42279" @default.
- W2586581179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5301212" @default.
- W2586581179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28186140" @default.
- W2586581179 hasPublicationYear "2017" @default.
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