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- W2586601476 endingPage "587" @default.
- W2586601476 startingPage "543" @default.
- W2586601476 abstract "Publisher SummaryThis chapter reveals that thyroid hormones refer to the products of the thyroid gland. Thyroid hormones are essential for brain maturation. Conditions that lead to reduced levels of thyroid hormone, such as iodine deficiency, congenital hypothyroidism, maternal hypothyroxinemia, and prematurity, are associated with different degrees of mental retardation and neurological symptoms. Fetal and neonatal hypothyroidism leads to hypomyelination, and to defects of cell migration and differentiation. Most actions of thyroid hormones are due to interactions of triiodothyronine (T3) with nuclear receptors, which are present in the rat from embryonal day 14, and in the human at least from the end of the first trimester of pregnancy. Brain T3 is, in great part, produced from thyroxine (T4) by the action of type II deiodinase." @default.
- W2586601476 created "2017-02-17" @default.
- W2586601476 creator A5042689915 @default.
- W2586601476 date "2002-01-01" @default.
- W2586601476 modified "2023-09-26" @default.
- W2586601476 title "Thyroid Hormones and Brain Development" @default.
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