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- W2586623476 abstract "Objective To explore the mechanism of LMWH therapy for SAP.Methods 48 wistar rats were random divided into 3 groups,sham group(S group),severe acute pancreatitis group(SAP group)and LMWH therapy group(H group).Serum amylase,IL-6,acinar cell apoptosis and the activity of NF-κB were detected and compared.Results The expression of amylase and IL-6 in SAP group was significantly higher than that in H group(P＜0.01).The apoptosis index of acinar cell in SAP group wag significantly lower than that in H group(P＜0.01),while the activity of NF-κB in SAP groupwas stronger than that in H group.Conclusions LMWH therapy may ameliorate SAP by inducing acinar cell apoptosis through suppressing the activity of NF-κB.Key words: Heparin,low-molecule-weight/PD; Pancreatitis/PP; Pancreas/CY; Apoptosis" @default.
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- W2586623476 date "2009-03-10" @default.
- W2586623476 modified "2023-09-24" @default.
- W2586623476 title "Experimental study of low molecular weight heparin inducing acinar cell apoptosis in severe acute pancreatitis" @default.
- W2586623476 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2009.03.018" @default.
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