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• W2586715399 abstract "The definition of a contribution of the carriage of the G1691A allele of thecoagulation factor V gene and the G20210A allele of the coagulation factor II gene in the development of thrombosis in Ph negative myeloprolifer ative neoplasms (MPN) patients, who were irradiated in the dose range 0,001 0,99 Gy and who were not.The clinical and molecular genetic characteristics of patients with radiation associated and spontaneous polycythemia vera (PV), essential trombotsytemiya (ET) and primary myelofibrosis (PMF) were ana lyzed. The group of radiation associated PV, ET and PMF represented by 35, 10 and 22 patients respectively, and the cohort of spontaneous PV, ET and PMF - 149, 111 and 78 patients respectively.The carriage of any of the two molecular genetic markers of hereditary thrombophilia at spontaneous PMF increases the frequency (3 of 6 vs 8 of 72; p = 0.033) and risk (RR = 6.09; 95 % CI = 1.40-26.43) of thrombosis. The presence of the G1691A allele of the proaccelerin gene in patients with PMF, who were not exposed to ionizing radiation, causes increase the likelihood of venous thrombosis at 10.14 times (95 % CI = 1.67-61.33). At spontaneous and radiation associated Ph negative MPN (in individuals exposed to doses in the range 0,001-0,99 Gy), the higher rate of the occurrence of venous, arterial and any thrombosis was observed in carriers of the G1691A allele the coagulation factor V gene, than in those, whose have the wild type allele. In particular, the G1691A allele of the proaccelerin gene carriers, that are belonged to the group of patients with radiation associated PV, have at 33.33 person years bigger rate of any thrombosis (95 % CI = 0.22-100.00, p = 0.048) and venous vascular events (95 % CI = 12.50-50.00; p = 0.003).In PMF patients with a radiation anamnesis were found the difference (20.00 person years; 95 % CI = 1.51-50.00, p = 0.035) between the ratio of any thrombosis and arterial vascular events, which was calculated for the G1691A allele of the proaccelerin gene and for those, who have the wild type allele. The carriers of the G20210A nucleotide variant of the coagulation factor II gene with spontaneous ET and PMF, compared with patients with the wild type allele, have a higher rate of venous thrombosis per 100 patient years.Meta. Vyznachennia vnesku nosiy̆stva G1691A alelia gena faktora V koaguliatsiï ta G20210A alelia gena faktora II ko aguliatsiï u vynyknennia tromboziv u khvorykh na Ph negatyvni miieloproliferatyvni novoutvorennia (MPN),op rominenykh v diapazoni doz 0,001–0,99 Gr ta bez oprominennia.Materialy ta metody. Proanalizovano klinichni ta molekuliarno genetychni kharakterystyky khvorykh na radiatsiy̆no asotsiy̆ovanu ta spontannu spravzhniu politsytemiiu (SP), esentsial'nu trombotsytemiiu (ET) i pervyn nyy̆ miielofibroz (PMF). Grupa radiatsiy̆no asotsiy̆ovanoï SP, ET ta PMF predstavlena 35, 10 ta 22 khvorymy vidpovidno, a kogorta spontannoï SP, ET ta PMF – 149, 111 i 78 patsiientamy vidpovidno.Rezul'taty ta vysnovky. Pry spontannomu PMF nosiy̆stvo bud' iakogo z dvokh molekuliarno genetychnykh markeriv spadkovoï trombofiliï zbil'shuie chastotu (3 iz 6 proty 8 iz 72; r = 0,033) ta ryzyk vynyknennia (VR = 6,09; 95 % DI = 1,40–26,43) tromboziv. Naiavnist' G1691A alelia gena proaktselerynu u khvorykh na PMF, iaki ne zaznaly vply vu ionizuiuchoï radiatsiï, zumovliuie zrostannia y̆movirnosti rozvytku tromboziv u venoznomu sudynnomu rusli v 10,14 raza (95 % DI = 1,67–61,33). Pry spontannykh i radiatsiy̆no asotsiy̆ovanykh Ph negatyvnykh MPN (v osib, op rominenykh u diapazoni doz 0,001–0,99 Gr) bil'shyy̆ koefitsiient vynyknennia venoznykh, arterial'nykh ta bud' iakykh tromboziv sposterigaiet'sia u nosiïv G1691A alelia gena faktoru V koaguliatsiï, nizh v osib z alelem dykogo typu. Zok rema, u nosiïv G1691A alelia gena proaktselerynu, iaki nalezhaly do grupy khvorykh na SP iz radiatsiy̆nym anamnezom, na 33,33 liudyno rokiv vyznacheno bil'shyy̆ koefitsiient vynyknennia bud' iakykh tromboziv (95 % DI = 0,22–100,00; r = 0,048) ta sudynnykh podiy̆ u venoznomu rusli (95% DI=12,50–50,00; r = 0,003). U khvorykh na PMF iz radiatsiy̆nym anamnezom takozh vyiavleno riznytsiu (20,00 liudyno rokiv; 95 % DI = 1,51–50,00; r = 0,035) mizh koefitsiientom vy nyknennia bud' iakykh tromboziv i arterial'nykh vaskuliarnykh podiy̆, rozrakhovanym dlia nosiïv G1691A alelia gena proaktselerynu ta dlia osib z alelem dykogo typu. U nosiïv nukleotydnogo varianta G20210A gena II faktora koa guliatsiï zi spontannoiu ET ta PMF, porivniano z patsiientamy z alelem dykogo typu, sposterigavsia bil'shyy̆ ko efitsiient z y̆ogo rozrakhunku na 100 liudyno rokiv rozvytku venoznykh tromboziv." @default.
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• W2586715399 date "2016-01-01" @default.
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• W2586715399 title "The contribution of hereditary thrombophilia to increasing the frequency of thrombosis in patients with Ph-negative myeloproliferative neoplasms, including the victims from the Chornobyl accident" @default.
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• W2586715399 doi "https://doi.org/10.33145/2304-8336-2016-21-291-311" @default.
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