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- W2586811424 abstract "Magnetic resonance imaging (MRI) has contributed to the field of tissue engineering and regenerative medicine (TERM) by providing a quantitative noninvasive assessment of tissue regeneration in the case of cartilage, bones, artificial livers, hearts, and many other organs and tissues. The visualization and quantitative assessment of tissue structure, tissue anisotropy, cell density and metabolism, extracellular matrix (ECM) production, the generation of new blood vessels, or the integration of implanted tissue with the host tissue can all be visualized and quantified via MRI. MRI offers an array of contrast mechanisms that can probe into the biochemical, physical, and mechanical properties of engineered tissues. Typically, water magnetic resonance (MR) parameters such as spin−lattice relaxation time (T 1), spin−spin relaxation time (T 2), T 1 in rotating frame (T 1rho), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and magnetization transfer (MT) ratio heat maps are used in the assessment of tissue growth and regeneration. The measurement of these parameters is based on the manipulation of water proton magnetization using radio-frequency (rf) pulses and magnetic field gradients that are at the heart of all MR image acquisition. In this chapter, the general MRI principles behind these applications are reviewed and some examples of MRI applications in the assessment of engineered tissues are provided." @default.
- W2586811424 created "2017-02-17" @default.
- W2586811424 creator A5080753695 @default.
- W2586811424 date "2017-02-08" @default.
- W2586811424 modified "2023-09-25" @default.
- W2586811424 title "Principles and Applications of Quantitative Parametric MRI in Tissue Engineering" @default.
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- W2586811424 doi "https://doi.org/10.1002/9781119193272.ch2" @default.
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