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• W2586845307 abstract "Objective: Bilateral audiometric notch (BN) at 4000–6000 Hz was identified as a noise-induced hearing loss (NIHL) phenotype for genetic association analysis in college-aged musicians. This study analysed BN in a sample of US youth. Design: Prevalence of the BN within the study sample was determined and logistic-regression analyses were performed to identify audiologic and other demographic factors associated with BN. Computer-simulated “flat” audiograms were used to estimate potential influence of false-positive rates in estimating the prevalence of the BN. Study sample: 2348 participants (12–19 years) following the inclusion criteria were selected from the National Health and Nutrition Examination Survey data (2005–2010). Results: The prevalence of BN was 16.6%. Almost 55.6% of the participants showed notch in at least one ear. Noise exposure, gender, ethnicity and age showed significant relationship with the BN. Computer simulation revealed that 5.5% of simulated participants with “flat” audiograms showed BN. Conclusion: Association of noise exposure with BN suggests that it is a useful NIHL phenotype for genetic association analyses. However, further research is necessary to reduce false-positive rates in notch identification." @default.
• W2586845307 created "2017-02-17" @default.
• W2586845307 creator A5064218589 @default.
• W2586845307 creator A5069904196 @default.
• W2586845307 date "2017-02-08" @default.
• W2586845307 modified "2023-10-14" @default.
• W2586845307 title "Analysis of audiometric notch as a noise-induced hearing loss phenotype in US youth: data from the National Health And Nutrition Examination Survey, 2005–2010" @default.
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• W2586845307 doi "https://doi.org/10.1080/14992027.2017.1278799" @default.
• W2586845307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28635495" @default.
• W2586845307 hasPublicationYear "2017" @default.
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