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- W2586895229 abstract "Establishing a functional blood supply in engineered tissue and doing so promptly remains one of the fundamental challenges to engineering and regenerating thick tissues and organs. Despite some success in this effort, creating a long-lasting vasculature that meets local metabolic demands will require a more cohesive and integrated investigation of the various strategies that have been identified to be promising, including cells, growth factors, and scaffolds. These investigations are best enabled by a noninvasive probe that can elucidate the mechanisms of action of different strategies and can monitor the time-course development of vascularization in a living subject. Magnetic resonance imaging (MRI) provides a suite of capabilities (e.g., dynamic contrast-enhanced imaging, vessel size imaging, blood-oxygen-level-dependent (BOLD) imaging, and molecular imaging) for noninvasively probing the physiological and molecular signatures of developing new vessels. This chapter reviews the current state of the art in MRI technology for the assessment of vascularized tissue and discusses the specific capabilities required in the tissue engineering setting." @default.
- W2586895229 created "2017-02-17" @default.
- W2586895229 creator A5029528071 @default.
- W2586895229 date "2017-02-08" @default.
- W2586895229 modified "2023-10-18" @default.
- W2586895229 title "MRI of Vascularized Tissue-Engineered Organs" @default.
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- W2586895229 doi "https://doi.org/10.1002/9781119193272.ch14" @default.
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