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- W2586922530 abstract "Aim: Cancer is among the leading causes of death worldwide. Medical interest has focused on macrocyclic polyamines because of their properties as antitumor agents. Results/Methodology: We have designed and synthesized a series of 1,2-diaminocyclohexane derivatives with notable in vitro antiproliferative activities against the MCF-7, HCT-116 and A375 cancer cell lines. Cell cycle and apoptosis analyses were also carried out. Our results show that all the compounds are potent cytotoxic agents, especially against the A375 cell line. Conclusion: The selective activity of the macrocyclic derivative against A375, via apoptosis, supposes a great advantage for future therapeutic use. This exemplifies the potential of 1,2-diaminocyclohexane derivatives to qualify as lead structures for future anticancer drug development due to their easy syntheses and noteworthy bioactivity." @default.
- W2586922530 created "2017-02-17" @default.
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- W2586922530 date "2017-03-01" @default.
- W2586922530 modified "2023-09-27" @default.
- W2586922530 title "Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells" @default.
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- W2586922530 doi "https://doi.org/10.4155/fmc-2016-0212" @default.
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