FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586931397> ?p ?o ?g. }

• W2586931397 endingPage "575" @default.
• W2586931397 startingPage "569" @default.
• W2586931397 abstract "The aim of this study was to determine the effects of garlic and ginkgo herbal extracts on the pharmacokinetics of the P-glycoprotein (P-gp)/organic anion-transporting polypeptides (Oatps) substrate fexofenadine. Male rats were dosed orally with garlic (120 mg/kg), ginkgo (17 mg/kg), St. John’s wort (SJW; 1000 mg/kg; positive control), or Milli-Q water for 14 days. On day 15, rats either were administered fexofenadine (orally or i.v.), had their livers isolated and perfused with fexofenadine, or had their small intestines divided into four segments (SI–SIV) and analyzed for P-gp and Oatp1a5. In vivo, SJW increased the clearance of i.v. administered fexofenadine by 28%. Garlic increased the area under the curve_0–∞ and maximum plasma concentration of orally administered fexofenadine by 47% and 85%, respectively. Ginkgo and SJW had no effect on the oral absorption of fexofenadine. In the perfused liver, garlic, ginkgo, and SJW increased the biliary clearance of fexofenadine with respect to perfusate by 71%, 121%, and 234%, respectively. SJW increased the biliary clearance relative to the liver concentration by 64%. The ratio of liver to perfusate concentrations significantly increased in all treated groups. The expression of Oatp1a5 in SI was increased by garlic (88%) and SJW (63%). There were no significant changes in the expression of P-gp. Induction of intestinal Oatp1a5 by garlic may explain the increased absorption of orally administered fexofenadine. Ginkgo had no effect on the expression of intestinal P-gp or Oatp1a5. A dual inductive effect by SJW on opposing intestinal epithelial transport by Oatp1a5 and P-gp remains a possibility." @default.
• W2586931397 created "2017-02-17" @default.
• W2586931397 creator A5029122725 @default.
• W2586931397 creator A5048094266 @default.
• W2586931397 creator A5049674178 @default.
• W2586931397 creator A5070752958 @default.
• W2586931397 date "2017-02-10" @default.
• W2586931397 modified "2023-10-09" @default.
• W2586931397 title "Effect of Garlic, Gingko, and St. John’s Wort Extracts on the Pharmacokinetics of Fexofenadine: A Mechanistic Study" @default.
• W2586931397 cites W1548404106 @default.
• W2586931397 cites W1560709301 @default.
• W2586931397 cites W1586303187 @default.
• W2586931397 cites W1794469725 @default.
• W2586931397 cites W1933364203 @default.
• W2586931397 cites W1970199287 @default.
• W2586931397 cites W1971041530 @default.
• W2586931397 cites W1975908811 @default.
• W2586931397 cites W1982708063 @default.
• W2586931397 cites W1998013298 @default.
• W2586931397 cites W2004424126 @default.
• W2586931397 cites W2004670440 @default.
• W2586931397 cites W2007074608 @default.
• W2586931397 cites W2012884604 @default.
• W2586931397 cites W2019960534 @default.
• W2586931397 cites W2020787591 @default.
• W2586931397 cites W2025292895 @default.
• W2586931397 cites W2027389537 @default.
• W2586931397 cites W2041799661 @default.
• W2586931397 cites W2041813321 @default.
• W2586931397 cites W2051163942 @default.
• W2586931397 cites W2054657245 @default.
• W2586931397 cites W2062683013 @default.
• W2586931397 cites W2062772862 @default.
• W2586931397 cites W2065141758 @default.
• W2586931397 cites W2066527804 @default.
• W2586931397 cites W2071172861 @default.
• W2586931397 cites W2076985436 @default.
• W2586931397 cites W2078121752 @default.
• W2586931397 cites W2081656085 @default.
• W2586931397 cites W2089569613 @default.
• W2586931397 cites W2104446368 @default.
• W2586931397 cites W2110615535 @default.
• W2586931397 cites W2123548631 @default.
• W2586931397 cites W2132806259 @default.
• W2586931397 cites W2133837027 @default.
• W2586931397 cites W2140975778 @default.
• W2586931397 cites W2141736423 @default.
• W2586931397 cites W2142783300 @default.
• W2586931397 cites W2150991974 @default.
• W2586931397 cites W2151696031 @default.
• W2586931397 cites W2153798421 @default.
• W2586931397 cites W2160350843 @default.
• W2586931397 cites W2167148987 @default.
• W2586931397 cites W87918361 @default.
• W2586931397 doi "https://doi.org/10.1124/dmd.116.073528" @default.
• W2586931397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28188296" @default.
• W2586931397 hasPublicationYear "2017" @default.
• W2586931397 type Work @default.
• W2586931397 sameAs 2586931397 @default.
• W2586931397 citedByCount "8" @default.
• W2586931397 countsByYear W25869313972018 @default.
• W2586931397 countsByYear W25869313972019 @default.
• W2586931397 countsByYear W25869313972021 @default.
• W2586931397 countsByYear W25869313972022 @default.
• W2586931397 countsByYear W25869313972023 @default.
• W2586931397 crossrefType "journal-article" @default.
• W2586931397 hasAuthorship W2586931397A5029122725 @default.
• W2586931397 hasAuthorship W2586931397A5048094266 @default.
• W2586931397 hasAuthorship W2586931397A5049674178 @default.
• W2586931397 hasAuthorship W2586931397A5070752958 @default.
• W2586931397 hasBestOaLocation W25869313971 @default.
• W2586931397 hasConcept C104317684 @default.
• W2586931397 hasConcept C112705442 @default.
• W2586931397 hasConcept C121332964 @default.
• W2586931397 hasConcept C125287762 @default.
• W2586931397 hasConcept C149011108 @default.
• W2586931397 hasConcept C185592680 @default.
• W2586931397 hasConcept C24890656 @default.
• W2586931397 hasConcept C2776678969 @default.
• W2586931397 hasConcept C2776711289 @default.
• W2586931397 hasConcept C2777056448 @default.
• W2586931397 hasConcept C2778998842 @default.
• W2586931397 hasConcept C2779303165 @default.
• W2586931397 hasConcept C2779706397 @default.
• W2586931397 hasConcept C2992379925 @default.
• W2586931397 hasConcept C55493867 @default.
• W2586931397 hasConcept C556039675 @default.
• W2586931397 hasConcept C71924100 @default.
• W2586931397 hasConcept C97320921 @default.
• W2586931397 hasConcept C98274493 @default.
• W2586931397 hasConceptScore W2586931397C104317684 @default.
• W2586931397 hasConceptScore W2586931397C112705442 @default.
• W2586931397 hasConceptScore W2586931397C121332964 @default.
• W2586931397 hasConceptScore W2586931397C125287762 @default.
• W2586931397 hasConceptScore W2586931397C149011108 @default.
• W2586931397 hasConceptScore W2586931397C185592680 @default.
• W2586931397 hasConceptScore W2586931397C24890656 @default.
• W2586931397 hasConceptScore W2586931397C2776678969 @default.

• next