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- W2586937063 abstract "Patients with ulcerative colitis (UC) have an increased risk of developing colorectal cancer (CRC). Surveillance colonoscopy is currently recommended for patients with long-standing extensive colitis for reducing CRC risk. Chemoprevention is an attractive complementary strategy. Areas covered: Inflammation is a major determinant of CRC risk and is potentially modifiable. Reducing inflammation is supposed to reduce CRC risk. Several medications have been evaluated in this setting: 5-ASA, thiopurines, anti-TNFα agents and ursodeoxycholic acid (UCDA) in patients with associated primary sclerosing cholangitis (PSC). This review offers a critical evaluation of current evidence of the potential chemopreventive effect of such medications. Expert commentary: No randomized controlled trials have been performed and the available evidence come from observational studies. Although biological plausibility supports a chemopreventive role of the aforementioned agents, the overall evidence of efficacy is weak because of several methodological limitations of the studies. Indirect epidemiological evidence, biologic plausibility and results of meta-analyses reasonably support a potential chemopreventive effect of 5-ASA. Available evidence does not support a specific chemopreventive effect of purine analogues and anti-TNFα medications, despite their efficacy in the management of inflammatory bowel disease. Data addressing UDCA and folate supplementation are inconclusive. Limited data are available for statins." @default.
- W2586937063 created "2017-02-17" @default.
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- W2586937063 date "2017-02-16" @default.
- W2586937063 modified "2023-09-23" @default.
- W2586937063 title "Chemoprevention of colorectal cancer in ulcerative colitis: digging deep in current evidence" @default.
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- W2586937063 cites W1617200419 @default.
- W2586937063 cites W1727714355 @default.
- W2586937063 cites W1964102710 @default.
- W2586937063 cites W1964220988 @default.
- W2586937063 cites W1967447048 @default.
- W2586937063 cites W1968821239 @default.
- W2586937063 cites W1972681156 @default.
- W2586937063 cites W1975019417 @default.
- W2586937063 cites W1975044459 @default.
- W2586937063 cites W1979648965 @default.
- W2586937063 cites W1983054413 @default.
- W2586937063 cites W1985082045 @default.
- W2586937063 cites W1990397098 @default.
- W2586937063 cites W1995596997 @default.
- W2586937063 cites W1999284872 @default.
- W2586937063 cites W1999788183 @default.
- W2586937063 cites W2008687669 @default.
- W2586937063 cites W2014776577 @default.
- W2586937063 cites W2015625787 @default.
- W2586937063 cites W2016321388 @default.
- W2586937063 cites W2019796203 @default.
- W2586937063 cites W2020892166 @default.
- W2586937063 cites W2024763754 @default.
- W2586937063 cites W2031992003 @default.
- W2586937063 cites W2033881351 @default.
- W2586937063 cites W2036563054 @default.
- W2586937063 cites W2037861078 @default.
- W2586937063 cites W2038572843 @default.
- W2586937063 cites W2040571623 @default.
- W2586937063 cites W2045123507 @default.
- W2586937063 cites W2045617306 @default.
- W2586937063 cites W2048717004 @default.
- W2586937063 cites W2055461186 @default.
- W2586937063 cites W2060190189 @default.
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- W2586937063 cites W2070299891 @default.
- W2586937063 cites W2071030966 @default.
- W2586937063 cites W2073410362 @default.
- W2586937063 cites W2075514229 @default.
- W2586937063 cites W2077105214 @default.
- W2586937063 cites W2078412324 @default.
- W2586937063 cites W2089292260 @default.
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- W2586937063 cites W2316014275 @default.
- W2586937063 cites W2330709704 @default.
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- W2586937063 doi "https://doi.org/10.1080/17474124.2017.1292129" @default.
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