Matches in SemOpenAlex for { <https://semopenalex.org/work/W2586999231> ?p ?o ?g. }
- W2586999231 abstract "Significance Intrinsically disordered regions (IDRs) are widespread, have diverse functions, and are involved in human disease. Because standard sequence analysis methods identify little sequence homology in IDRs, it is not currently understood whether (or how) the functions of these protein regions are preserved over evolution. Here we show that orthologous IDRs can preserve regulatory functions despite near-complete sequence divergence. This suggests that natural selection maintains aggregate molecular properties in IDRs, which we propose to be quantitative traits. Consistent with this, we find signatures of stabilizing selection on the electrostatic properties of IDRs. Thus, in analogy to the rapid evolution of noncoding DNA in eukaryotic enhancers, divergence in primary amino acid sequence does not imply functional divergence in IDRs." @default.
- W2586999231 created "2017-02-17" @default.
- W2586999231 creator A5016343383 @default.
- W2586999231 creator A5047578407 @default.
- W2586999231 creator A5048514799 @default.
- W2586999231 creator A5086545231 @default.
- W2586999231 date "2017-02-06" @default.
- W2586999231 modified "2023-09-30" @default.
- W2586999231 title "Selection maintains signaling function of a highly diverged intrinsically disordered region" @default.
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- W2586999231 doi "https://doi.org/10.1073/pnas.1614787114" @default.
- W2586999231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5338452" @default.
- W2586999231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28167781" @default.