FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587017561> ?p ?o ?g. }

• W2587017561 endingPage "90" @default.
• W2587017561 startingPage "80" @default.
• W2587017561 abstract "Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc). Mitochondrial dysfunction and cell apoptosis are suggested to be actively involved in the pathogenesis of PD. In the present study, the neuroprotective effect of amentoflavone (AF), a naturally occurring biflavonoid from Selaginella tamariscina, was examined in PD models both in vitro and in vivo. On SH-SY5Y cells, AF treatment dose-dependently reduced 1-methyl-4-phenylpyridinium (MPP+)-induced nuclear condensation and loss of cell viability without obvious cytotoxicity. It inhibited the activation of caspase-3 and p21 but increased the Bcl-2/Bax ratio. Further study disclosed that AF enhanced the phosphorylation of PI3K, Akt and ERK1/2 down-regulated by MPP+ in SH-SY5Y cells, the effect of which could be blocked by LY294002, the inhibitor of PI3K. Consistently, AF alleviated the behavioral deterioration in pole and traction tests and rescued the loss of dopaminergic neurons in SNpc and fibers in striatum in methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mice. It also could enhance the activation of PI3K and Akt as well as Bcl-2/Bax ratio in SN. Moreover, AF alleviated gliosis as well as the gene expression levels of IL-1β and iNOS in SN. Collectively, these results suggested that AF protected dopaminergic neurons against MPTP/MPP+-induced neurotoxicity, which might be mediated through activation of PI3K/Akt and ERK signaling pathways in dopaminergic neurons and attenuation of neuroinflammation." @default.
• W2587017561 created "2017-02-17" @default.
• W2587017561 creator A5006507411 @default.
• W2587017561 creator A5024363666 @default.
• W2587017561 creator A5024963559 @default.
• W2587017561 creator A5034614651 @default.
• W2587017561 creator A5046650649 @default.
• W2587017561 creator A5049578678 @default.
• W2587017561 creator A5057356667 @default.
• W2587017561 creator A5063549540 @default.
• W2587017561 creator A5076403451 @default.
• W2587017561 creator A5085903306 @default.
• W2587017561 date "2017-03-01" @default.
• W2587017561 modified "2023-10-02" @default.
• W2587017561 title "Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways" @default.
• W2587017561 cites W1099853380 @default.
• W2587017561 cites W1523576195 @default.
• W2587017561 cites W1525862648 @default.
• W2587017561 cites W1535426243 @default.
• W2587017561 cites W1752687264 @default.
• W2587017561 cites W1830713541 @default.
• W2587017561 cites W1923453095 @default.
• W2587017561 cites W1976598386 @default.
• W2587017561 cites W1980585130 @default.
• W2587017561 cites W1991690797 @default.
• W2587017561 cites W1993640550 @default.
• W2587017561 cites W2000315672 @default.
• W2587017561 cites W2000424893 @default.
• W2587017561 cites W2011341174 @default.
• W2587017561 cites W2016397745 @default.
• W2587017561 cites W2016639408 @default.
• W2587017561 cites W2027887708 @default.
• W2587017561 cites W2030157319 @default.
• W2587017561 cites W2043075342 @default.
• W2587017561 cites W2043575317 @default.
• W2587017561 cites W2047616407 @default.
• W2587017561 cites W2059004906 @default.
• W2587017561 cites W2061858094 @default.
• W2587017561 cites W2065519256 @default.
• W2587017561 cites W2082620184 @default.
• W2587017561 cites W2086455336 @default.
• W2587017561 cites W2087877138 @default.
• W2587017561 cites W2092329172 @default.
• W2587017561 cites W2093996370 @default.
• W2587017561 cites W2108362964 @default.
• W2587017561 cites W2111065594 @default.
• W2587017561 cites W2112112294 @default.
• W2587017561 cites W2112763569 @default.
• W2587017561 cites W2118798870 @default.
• W2587017561 cites W2128752618 @default.
• W2587017561 cites W2134886133 @default.
• W2587017561 cites W2150074066 @default.
• W2587017561 cites W2152070721 @default.
• W2587017561 cites W2152123492 @default.
• W2587017561 cites W2164165561 @default.
• W2587017561 cites W2178310506 @default.
• W2587017561 cites W2181116576 @default.
• W2587017561 cites W2182813422 @default.
• W2587017561 cites W2199406275 @default.
• W2587017561 cites W2277941724 @default.
• W2587017561 cites W2296034313 @default.
• W2587017561 cites W2401558812 @default.
• W2587017561 cites W62603772 @default.
• W2587017561 doi "https://doi.org/10.1016/j.taap.2017.01.019" @default.
• W2587017561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28185818" @default.
• W2587017561 hasPublicationYear "2017" @default.
• W2587017561 type Work @default.
• W2587017561 sameAs 2587017561 @default.
• W2587017561 citedByCount "86" @default.
• W2587017561 countsByYear W25870175612017 @default.
• W2587017561 countsByYear W25870175612018 @default.
• W2587017561 countsByYear W25870175612019 @default.
• W2587017561 countsByYear W25870175612020 @default.
• W2587017561 countsByYear W25870175612021 @default.
• W2587017561 countsByYear W25870175612022 @default.
• W2587017561 countsByYear W25870175612023 @default.
• W2587017561 crossrefType "journal-article" @default.
• W2587017561 hasAuthorship W2587017561A5006507411 @default.
• W2587017561 hasAuthorship W2587017561A5024363666 @default.
• W2587017561 hasAuthorship W2587017561A5024963559 @default.
• W2587017561 hasAuthorship W2587017561A5034614651 @default.
• W2587017561 hasAuthorship W2587017561A5046650649 @default.
• W2587017561 hasAuthorship W2587017561A5049578678 @default.
• W2587017561 hasAuthorship W2587017561A5057356667 @default.
• W2587017561 hasAuthorship W2587017561A5063549540 @default.
• W2587017561 hasAuthorship W2587017561A5076403451 @default.
• W2587017561 hasAuthorship W2587017561A5085903306 @default.
• W2587017561 hasConcept C137183658 @default.
• W2587017561 hasConcept C169760540 @default.
• W2587017561 hasConcept C178790620 @default.
• W2587017561 hasConcept C185592680 @default.
• W2587017561 hasConcept C203014093 @default.
• W2587017561 hasConcept C25498285 @default.
• W2587017561 hasConcept C2776773494 @default.
• W2587017561 hasConcept C2776914184 @default.
• W2587017561 hasConcept C2778674702 @default.
• W2587017561 hasConcept C2779491297 @default.
• W2587017561 hasConcept C2780938664 @default.

• next