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• W2587101509 abstract "Retrospective evidence suggest an impact of the local control on survival in patients with MBC. A potential cause is the presence of LLS after PT removal. The aim was to assess the proportion of LLS after PT removal versus no surgery and the impact of age. A retrospective study was performed between February 1982 and September 2005 in our institution. In order to minimize selection bias patients > 80y, with median follow-up <90 days and Charlson score >2 were excluded. An univariate and multivariate analysis of surgery and other prognostic variables was performed. Overall survival (OS) was calculated with Kaplan-Meier (KM). Probability of LLS was considered for patients with survival >120 months. Analyses were performed for the whole series, <65 and >65 years old cohorts. 192 pts with MBC at diagnosis were recruited, of whom 112 underwent excision of the PT (Surgery group) and 80 pts did not received local therapy (Non-surgery group). Median age was 56 (48-65) for Surgery and 59 (51-70) for Non-surgery group. Operated patients were more likely to have only 1 site of metastasis. In the univariate analysis removal of PT, ER, PR, PS and number of metastatic sites were significantly related with OS. However only removal of PT and ER remained as independent prognostic factors in the multivariate analysis. With a median follow-up of 67.7 months, OS was significantly superior in Surgery group (40.7 vs 22 months, p < 0.001). Proportion of LLS was 16.7% vs 4.4% in surgery vs non-surgery group. KM for OS in the subgroup of < 65 showed similar results with median of 40.7 vs 22.0 months (p < 0.001) and LLS of 19.9% vs 2.1%. In this group removal of PT, ER and bone-disease only were significant in multivariate analysis. Of note in >65 years surgery had no benefit in OS (log rank p = 0.340) and LLS of 14.0% vs 8.1% in surgery vs non-surgery group. In this group Charlson score was a significant prognostic factor for survival in this cohort. Surgical excision of PT in younger patients with ER+ and small number of metastatic sites seems to have an impact in achieving an important proportion of LLS. No benefit in >65 years was seen." @default.
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• W2587101509 date "2016-10-01" @default.
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• W2587101509 title "Long lasting survival (LLS) after removal of primary tumor (PT) in metastatic breast cancer (MBC). Impact of age on outcome" @default.
• W2587101509 doi "https://doi.org/10.1093/annonc/mdw365.31" @default.
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