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- W2587138214 abstract ": Biliary tract cancers (BTC)/Cholangiocarcinoma (CCA) is an aggressive biliary tract epithelial malignancy from varying locations within the biliary tree with cholangiocyte depreciation., including intrahepatic cholangiocarcinoma (iCCA) (iCCA), extrahepatic cholangiocarcinoma (eCCA) and gallbladder carcinoma (GBC). The disease is largely heterogeneous in etiology, epidemiology, and molecular profile. There are limited treatment options and low survival rates for those patients with advanced or metastatic disease. Systemic treatment is confined to cytotoxic chemotherapy with the combination of gemcitabine and cisplatin. Lack of a stereotype genetic signature makes difficult in identification of potential actionable target directly, which may also explain lack of obvious clinic benefit with target oriented agents from current studies. It is crucial to understand of BTC carcinogenesis, tumor-stroma interactions, and key molecular pathways, and herald to establish targeted, individualized therapies for the heterogeneous disease, and eventually to improve the survival and overall outcome of patients." @default.
- W2587138214 created "2017-02-17" @default.
- W2587138214 creator A5009507489 @default.
- W2587138214 creator A5019734570 @default.
- W2587138214 date "2017-04-01" @default.
- W2587138214 modified "2023-09-27" @default.
- W2587138214 title "Targeted therapy in biliary tract cancers—current limitations and potentials in the future" @default.
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- W2587138214 cites W1534102370 @default.
- W2587138214 cites W1566871294 @default.
- W2587138214 cites W179620888 @default.
- W2587138214 cites W1806572515 @default.
- W2587138214 cites W1891752511 @default.
- W2587138214 cites W1908187732 @default.
- W2587138214 cites W1911108481 @default.
- W2587138214 cites W1921236192 @default.
- W2587138214 cites W1935364245 @default.
- W2587138214 cites W1940241680 @default.
- W2587138214 cites W1964688722 @default.
- W2587138214 cites W1968773418 @default.
- W2587138214 cites W1989145928 @default.
- W2587138214 cites W1995732721 @default.
- W2587138214 cites W1995783757 @default.
- W2587138214 cites W1996520070 @default.
- W2587138214 cites W2011836194 @default.
- W2587138214 cites W2012887353 @default.
- W2587138214 cites W2015613033 @default.
- W2587138214 cites W2021080683 @default.
- W2587138214 cites W2025130792 @default.
- W2587138214 cites W2025769688 @default.
- W2587138214 cites W2029037503 @default.
- W2587138214 cites W2038787775 @default.
- W2587138214 cites W2042048917 @default.
- W2587138214 cites W2046685969 @default.
- W2587138214 cites W2049703514 @default.
- W2587138214 cites W2055424532 @default.
- W2587138214 cites W2060221454 @default.
- W2587138214 cites W2060785128 @default.
- W2587138214 cites W2062628269 @default.
- W2587138214 cites W2063432158 @default.
- W2587138214 cites W2065134430 @default.
- W2587138214 cites W2065756402 @default.
- W2587138214 cites W2066967801 @default.
- W2587138214 cites W2067486928 @default.
- W2587138214 cites W2067892704 @default.
- W2587138214 cites W2068110847 @default.
- W2587138214 cites W2071862424 @default.
- W2587138214 cites W2073346844 @default.
- W2587138214 cites W2075383318 @default.
- W2587138214 cites W2082095140 @default.
- W2587138214 cites W2082656764 @default.
- W2587138214 cites W2089609513 @default.
- W2587138214 cites W2090446824 @default.
- W2587138214 cites W2093388808 @default.
- W2587138214 cites W2094501197 @default.
- W2587138214 cites W2095196969 @default.
- W2587138214 cites W2096390455 @default.
- W2587138214 cites W2096888043 @default.
- W2587138214 cites W2097924418 @default.
- W2587138214 cites W2097968583 @default.
- W2587138214 cites W2099386389 @default.
- W2587138214 cites W2101036284 @default.
- W2587138214 cites W2101397109 @default.
- W2587138214 cites W2113222623 @default.
- W2587138214 cites W2114327118 @default.
- W2587138214 cites W2115261608 @default.
- W2587138214 cites W2117050193 @default.
- W2587138214 cites W2118520585 @default.
- W2587138214 cites W2123767664 @default.
- W2587138214 cites W2132215313 @default.
- W2587138214 cites W2136264959 @default.
- W2587138214 cites W2137875447 @default.
- W2587138214 cites W2137897056 @default.
- W2587138214 cites W2138896702 @default.
- W2587138214 cites W2139947970 @default.
- W2587138214 cites W2141042450 @default.
- W2587138214 cites W2145857211 @default.
- W2587138214 cites W2152221138 @default.
- W2587138214 cites W2157232767 @default.
- W2587138214 cites W2168106806 @default.
- W2587138214 cites W2169106066 @default.
- W2587138214 cites W2171559250 @default.
- W2587138214 cites W2188928518 @default.
- W2587138214 cites W2261129417 @default.
- W2587138214 cites W4211025847 @default.
- W2587138214 cites W4250885086 @default.
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- W2587138214 doi "https://doi.org/10.21037/jgo.2016.09.16" @default.
- W2587138214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5401865" @default.
- W2587138214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28480071" @default.
- W2587138214 hasPublicationYear "2017" @default.
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