Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587183199> ?p ?o ?g. }
- W2587183199 endingPage "5035" @default.
- W2587183199 startingPage "5031" @default.
- W2587183199 abstract "Docetaxel, recognized as a stabilizing microtubule agent, is frequently administrated as a first line treatment for prostate cancers. Due to high side effects of monotherapy, however, combinations with novel adjuvants have emerged as an alternative strategy in cancer therapy protocols. Here, we investigated the combined effects of stattic and docetaxel on the DU145 prostate cancer cell line. Cytotoxicity was evaluated by MTT assay. To understand molecular mechanisms of stattic action, apoptotic related genes including Bcl-2, Mcl-1, Survivin and Bax were evaluated by real-time RT-PCR. Alteration in the expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 genes and Bax/Bcl-2 ratio were investigated via the 2ΔΔCT method. The IC50 values for docetaxel and stattic were 3.7 ± 0.9 nM and 4.6±0.8 μM, respectively. Evaluation of key gene expression levels revealed a noticeable decrease in antiapoptotic Bcl-2 and Mcl-1 along with an increase in pro-apoptotic Bax mRNA levels (p<0.05). Our results suggest that combination of a STAT3 inhibitor with doctaxel can be considered as a potent strategy for induction of apoptosis via increasing Bax mRNA expression." @default.
- W2587183199 created "2017-02-17" @default.
- W2587183199 creator A5003250850 @default.
- W2587183199 creator A5005511441 @default.
- W2587183199 creator A5012844763 @default.
- W2587183199 creator A5068279960 @default.
- W2587183199 creator A5072829826 @default.
- W2587183199 date "2016-11-01" @default.
- W2587183199 modified "2023-10-04" @default.
- W2587183199 title "Combined Treatment with Stattic and Docetaxel Alters the Bax/Bcl-2 Gene Expression Ratio in Human Prostate Cancer Cells" @default.
- W2587183199 cites W181281151 @default.
- W2587183199 cites W1882528117 @default.
- W2587183199 cites W1979103878 @default.
- W2587183199 cites W2005112594 @default.
- W2587183199 cites W2025977869 @default.
- W2587183199 cites W2027779353 @default.
- W2587183199 cites W2028544780 @default.
- W2587183199 cites W2036564735 @default.
- W2587183199 cites W2041811632 @default.
- W2587183199 cites W2080356582 @default.
- W2587183199 cites W2083911670 @default.
- W2587183199 cites W2088883749 @default.
- W2587183199 cites W2089334373 @default.
- W2587183199 cites W2100304113 @default.
- W2587183199 cites W2102912734 @default.
- W2587183199 cites W2116585100 @default.
- W2587183199 cites W2117897121 @default.
- W2587183199 cites W2120815949 @default.
- W2587183199 cites W2137228442 @default.
- W2587183199 cites W2143780280 @default.
- W2587183199 cites W2153216949 @default.
- W2587183199 cites W2159372512 @default.
- W2587183199 cites W2169700609 @default.
- W2587183199 cites W2170552969 @default.
- W2587183199 cites W2231176282 @default.
- W2587183199 cites W2235867054 @default.
- W2587183199 cites W2258708832 @default.
- W2587183199 cites W2343305829 @default.
- W2587183199 cites W2403180991 @default.
- W2587183199 cites W2435180223 @default.
- W2587183199 cites W2462246105 @default.
- W2587183199 cites W2467139254 @default.
- W2587183199 cites W2516496630 @default.
- W2587183199 cites W2518440501 @default.
- W2587183199 cites W7690840 @default.
- W2587183199 doi "https://doi.org/10.22034/apjcp.2016.17.11.5031" @default.
- W2587183199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5454715" @default.
- W2587183199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28032735" @default.
- W2587183199 hasPublicationYear "2016" @default.
- W2587183199 type Work @default.
- W2587183199 sameAs 2587183199 @default.
- W2587183199 citedByCount "13" @default.
- W2587183199 countsByYear W25871831992017 @default.
- W2587183199 countsByYear W25871831992018 @default.
- W2587183199 countsByYear W25871831992019 @default.
- W2587183199 countsByYear W25871831992020 @default.
- W2587183199 countsByYear W25871831992021 @default.
- W2587183199 countsByYear W25871831992022 @default.
- W2587183199 countsByYear W25871831992023 @default.
- W2587183199 crossrefType "journal-article" @default.
- W2587183199 hasAuthorship W2587183199A5003250850 @default.
- W2587183199 hasAuthorship W2587183199A5005511441 @default.
- W2587183199 hasAuthorship W2587183199A5012844763 @default.
- W2587183199 hasAuthorship W2587183199A5068279960 @default.
- W2587183199 hasAuthorship W2587183199A5072829826 @default.
- W2587183199 hasConcept C104317684 @default.
- W2587183199 hasConcept C121608353 @default.
- W2587183199 hasConcept C126322002 @default.
- W2587183199 hasConcept C150194340 @default.
- W2587183199 hasConcept C185592680 @default.
- W2587183199 hasConcept C190283241 @default.
- W2587183199 hasConcept C2775975398 @default.
- W2587183199 hasConcept C2776438761 @default.
- W2587183199 hasConcept C2779723316 @default.
- W2587183199 hasConcept C2780192828 @default.
- W2587183199 hasConcept C2780783641 @default.
- W2587183199 hasConcept C2781190966 @default.
- W2587183199 hasConcept C502942594 @default.
- W2587183199 hasConcept C54355233 @default.
- W2587183199 hasConcept C71924100 @default.
- W2587183199 hasConcept C86803240 @default.
- W2587183199 hasConceptScore W2587183199C104317684 @default.
- W2587183199 hasConceptScore W2587183199C121608353 @default.
- W2587183199 hasConceptScore W2587183199C126322002 @default.
- W2587183199 hasConceptScore W2587183199C150194340 @default.
- W2587183199 hasConceptScore W2587183199C185592680 @default.
- W2587183199 hasConceptScore W2587183199C190283241 @default.
- W2587183199 hasConceptScore W2587183199C2775975398 @default.
- W2587183199 hasConceptScore W2587183199C2776438761 @default.
- W2587183199 hasConceptScore W2587183199C2779723316 @default.
- W2587183199 hasConceptScore W2587183199C2780192828 @default.
- W2587183199 hasConceptScore W2587183199C2780783641 @default.
- W2587183199 hasConceptScore W2587183199C2781190966 @default.
- W2587183199 hasConceptScore W2587183199C502942594 @default.
- W2587183199 hasConceptScore W2587183199C54355233 @default.
- W2587183199 hasConceptScore W2587183199C71924100 @default.
- W2587183199 hasConceptScore W2587183199C86803240 @default.
- W2587183199 hasIssue "11" @default.