Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587276077> ?p ?o ?g. }
- W2587276077 endingPage "89" @default.
- W2587276077 startingPage "80" @default.
- W2587276077 abstract "Osteoporosis, the most common bone metabolic disease affecting nearly 200 million people worldwide is under the strong influence of genetic components. Simultaneously, adipogenesis and osteogenesis are two highly coordinated processes imperative for the maintenance of bone quality and quantity, where any perturbation leads to pathological conditions of obesity, osteopenia and osteoporosis. To delineate this adipogenic-osteogenic connection, a total of 254 cases (T-score<-1.0 SD) and 250 age, gender and ethnicity matched healthy controls (T-score≥-1.0 SD) were recruited from North India after analyzing bone health status employing quantitative ultrasound (QUS) bone densitometer. The genetic variants of Perilipin 1 (PLIN1), Complement Factor D (CFD) and Adiponectin (ADIPOQ) were genotyped using the PCR-RFLP/ARMS-PCR approach. Subjects with CC+CT (PLIN1 rs2304795) and CC+CG (CFD rs1683563) genotypes conferred nearly 1.54-1.87 fold increased risk towards bone deterioration. Predicted RNA secondary structures of rs2304795 corroborated the risk associated with wild type C allele. G allele carriers at the ADIPOQ locus (rs1501299) were more likely to have a lower bone health (1.57-fold). Haplotype analysis revealed the ADIPOQ variants rs1501299 and rs3774261 in slight linkage disequilibrium (LD), nonetheless G/G haplotype was associated with increased risk. 3-locus and 5-locus gene-gene interaction models revealed a greater likelihood of bone deterioration. In conclusion, certain variants of adipogenic genes might serve as potential biomarkers for determining the genetic predisposition towards bone loss in the North Indian population, further, emphasizing the role of impaired metabolism in bone health." @default.
- W2587276077 created "2017-02-17" @default.
- W2587276077 creator A5023209676 @default.
- W2587276077 creator A5041166391 @default.
- W2587276077 creator A5042013209 @default.
- W2587276077 creator A5044408150 @default.
- W2587276077 creator A5066539656 @default.
- W2587276077 creator A5087346962 @default.
- W2587276077 creator A5091340733 @default.
- W2587276077 date "2017-04-01" @default.
- W2587276077 modified "2023-10-13" @default.
- W2587276077 title "Associating genetic variation at Perilipin 1, Complement Factor D and Adiponectin loci to the bone health status in North Indian population" @default.
- W2587276077 cites W1539474775 @default.
- W2587276077 cites W1548392410 @default.
- W2587276077 cites W1558241080 @default.
- W2587276077 cites W1563977056 @default.
- W2587276077 cites W17930463 @default.
- W2587276077 cites W1895078941 @default.
- W2587276077 cites W1963619735 @default.
- W2587276077 cites W1964815707 @default.
- W2587276077 cites W1967994744 @default.
- W2587276077 cites W1968120221 @default.
- W2587276077 cites W1969375002 @default.
- W2587276077 cites W1970791713 @default.
- W2587276077 cites W1971585165 @default.
- W2587276077 cites W1973837001 @default.
- W2587276077 cites W1987176983 @default.
- W2587276077 cites W1987552787 @default.
- W2587276077 cites W1988627271 @default.
- W2587276077 cites W1988892013 @default.
- W2587276077 cites W1991397788 @default.
- W2587276077 cites W1991610154 @default.
- W2587276077 cites W1997978122 @default.
- W2587276077 cites W1999680840 @default.
- W2587276077 cites W2006643266 @default.
- W2587276077 cites W2007047209 @default.
- W2587276077 cites W2007934093 @default.
- W2587276077 cites W2010030857 @default.
- W2587276077 cites W2015496410 @default.
- W2587276077 cites W2015739140 @default.
- W2587276077 cites W2015792196 @default.
- W2587276077 cites W2017918734 @default.
- W2587276077 cites W2018364229 @default.
- W2587276077 cites W2018928635 @default.
- W2587276077 cites W2019282933 @default.
- W2587276077 cites W2019609807 @default.
- W2587276077 cites W2031122764 @default.
- W2587276077 cites W2031502981 @default.
- W2587276077 cites W2038966821 @default.
- W2587276077 cites W2039632322 @default.
- W2587276077 cites W2040845651 @default.
- W2587276077 cites W2044051773 @default.
- W2587276077 cites W2046248373 @default.
- W2587276077 cites W2046961412 @default.
- W2587276077 cites W2050080529 @default.
- W2587276077 cites W2051051060 @default.
- W2587276077 cites W2052039990 @default.
- W2587276077 cites W2054397642 @default.
- W2587276077 cites W2054837140 @default.
- W2587276077 cites W2059511498 @default.
- W2587276077 cites W2062021473 @default.
- W2587276077 cites W2063705809 @default.
- W2587276077 cites W2066950474 @default.
- W2587276077 cites W2067561975 @default.
- W2587276077 cites W2069967113 @default.
- W2587276077 cites W2070358670 @default.
- W2587276077 cites W2075452212 @default.
- W2587276077 cites W2082503461 @default.
- W2587276077 cites W2085807537 @default.
- W2587276077 cites W2089598881 @default.
- W2587276077 cites W2090050473 @default.
- W2587276077 cites W2090785255 @default.
- W2587276077 cites W2094744133 @default.
- W2587276077 cites W2097474764 @default.
- W2587276077 cites W2098286471 @default.
- W2587276077 cites W2098627598 @default.
- W2587276077 cites W2103250001 @default.
- W2587276077 cites W2103723120 @default.
- W2587276077 cites W2108065192 @default.
- W2587276077 cites W2110919070 @default.
- W2587276077 cites W2116404316 @default.
- W2587276077 cites W2118210818 @default.
- W2587276077 cites W2121202701 @default.
- W2587276077 cites W2123292266 @default.
- W2587276077 cites W2126631212 @default.
- W2587276077 cites W2130319127 @default.
- W2587276077 cites W2130660012 @default.
- W2587276077 cites W2131878646 @default.
- W2587276077 cites W2131911193 @default.
- W2587276077 cites W2131914513 @default.
- W2587276077 cites W2132022105 @default.
- W2587276077 cites W2132963003 @default.
- W2587276077 cites W2138130607 @default.
- W2587276077 cites W2138334499 @default.
- W2587276077 cites W2147921895 @default.
- W2587276077 cites W2150481940 @default.
- W2587276077 cites W2151332731 @default.
- W2587276077 cites W2151715711 @default.