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- W2587292756 abstract "Introduction: Adipophilin (ADRP/ADPH/PLIN2), a member of theperilipin (PAT) family of lipid droplet proteins, is believedto play a crucial role in both formation and secretion of milklipids in mammals. The aim of our study was to determinewhether adipophilin is secreted into human breast milk and toassociate adipophilin levels in breast milk with the exonicvariations of the adipophilin gene. Material and methods: Thetotal of 20 pregnant women with physiological pregnancy,originating from the Caucasian Central-European population,were enrolled into the study and serum-milk sample duos werecollected at the time of birth and at the days 1-3, 12-14,28-30, 88-90 and 178-180 postpartum and investigated usingELISA-based methodology. The exons 3-7 of the PLIN2 gene weredirectly sequenced.Results: Adipophilin was constantly secretedinto breast milk during the whole period of the study. Thematernal serum circulating levels were extremely low (<0.8ug/l), while the adipophilin levels in breast milksubstantially exceeded serum levels at the given timepoints (p= 0.03). Two SNPs in exonic sequence of PLIN2 gene wereidentified, synonymous rs2228416 and missense rs35568725 thatwere not associated with maternal serum / breast milk levels ofadipophilin. Conclusion: This is the first study to demonstratethat adipophilin is secreted into human breast milk during thewhole 6 months after the birth. We do not report majorassociation of investigated exonic variations of PLIN2 genewith adipophilin levels in maternal serum / breast milk in theCentral- European population." @default.
- W2587292756 created "2017-02-17" @default.
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- W2587292756 date "2012-06-24" @default.
- W2587292756 modified "2023-10-04" @default.
- W2587292756 title "Adipophilin (ADRP/ADPH/PLIN2): Variability in Exonic Regionsand Secretion of Adipophilin into Breast Milk" @default.
- W2587292756 hasPublicationYear "2012" @default.
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