Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587293770> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2587293770 abstract "Heparin-induced thrombocytopenia (HIT) can cause fatal arterial or venous thrombosis/thromboembolism. In high-risk cases, heparin should be immediately discontinued and an alternative administered; the only alternative permitted in Japan is argatroban, a direct thrombin inhibitor. Anticoagulation in patients with recent HIT requiring cardiopulmonary bypass (CPB) surgery is challenging, because it is sometimes difficult to find out appropriate dosage of argatroban using ACT based monitoring calculation.Two dilated cardiomyopathy patients with HIT were administered argatroban as the anticoagulant for the CPB in left ventricular assist device (LVAD) implantation. After discontinuing argatroban, blood coagulopathy persisted beyond its expected half-life, leading to abnormal haemostasis. Because of severe intraoperative and postoperative bleeding, both patients required massive transfusion support, despite the case 2 performed plasmapheresis to eliminate argatroban at the weaning from CPB. However, blood loss in case 2 (18,159 ml) was significantly lower than that in case 1 (31,292 ml), which might be contributed by the smaller dosage of argatroban (242 mg in case 2 vs. 489 mg in case 1) and plasmapheresis.Prolongation of ACT is multifactorial and affected by platelet count, fibrinogen concentration and, particularly total dose of argatroban. Furthermore, literatures and our experienses revealed that the recovery time to baseline ACT after stopping argatroban was significantly correlated with the total dose of argatroban (r=0.927). But, we could not authenticate the potency of plasmapheresis to eliminate argatroban and HIT antibodies.Because no specific antidotes are available for argatroban, surgical teams should carefully monitor timing of argatroban administration and the total dosage." @default.
- W2587293770 created "2017-02-17" @default.
- W2587293770 creator A5080883643 @default.
- W2587293770 date "2015-01-01" @default.
- W2587293770 modified "2023-09-25" @default.
- W2587293770 title "Anticoagulant Managements of Left Ventricular Assist Device Implantation in Two Patients with Heparin-Induced Thrombocytopenia (HIT): Use of Argatroban as an Anticoagulant for Cardiopulmonary Bypass" @default.
- W2587293770 cites W124032993 @default.
- W2587293770 cites W1964304312 @default.
- W2587293770 cites W1966427919 @default.
- W2587293770 cites W1986117726 @default.
- W2587293770 cites W1994357312 @default.
- W2587293770 cites W2006780952 @default.
- W2587293770 cites W2024534153 @default.
- W2587293770 cites W2070676143 @default.
- W2587293770 cites W2073637661 @default.
- W2587293770 cites W2082188869 @default.
- W2587293770 cites W2112564023 @default.
- W2587293770 cites W2114902654 @default.
- W2587293770 cites W2126850862 @default.
- W2587293770 cites W2167696721 @default.
- W2587293770 cites W2400681311 @default.
- W2587293770 cites W2441247466 @default.
- W2587293770 cites W2508035518 @default.
- W2587293770 doi "https://doi.org/10.4172/2155-6148.1000525" @default.
- W2587293770 hasPublicationYear "2015" @default.
- W2587293770 type Work @default.
- W2587293770 sameAs 2587293770 @default.
- W2587293770 citedByCount "5" @default.
- W2587293770 countsByYear W25872937702015 @default.
- W2587293770 crossrefType "journal-article" @default.
- W2587293770 hasAuthorship W2587293770A5080883643 @default.
- W2587293770 hasBestOaLocation W25872937701 @default.
- W2587293770 hasConcept C126322002 @default.
- W2587293770 hasConcept C141071460 @default.
- W2587293770 hasConcept C159654299 @default.
- W2587293770 hasConcept C164705383 @default.
- W2587293770 hasConcept C203014093 @default.
- W2587293770 hasConcept C2776301958 @default.
- W2587293770 hasConcept C2776472838 @default.
- W2587293770 hasConcept C2776710957 @default.
- W2587293770 hasConcept C2777292125 @default.
- W2587293770 hasConcept C2777557582 @default.
- W2587293770 hasConcept C2778205648 @default.
- W2587293770 hasConcept C2778810321 @default.
- W2587293770 hasConcept C2778842783 @default.
- W2587293770 hasConcept C2778881276 @default.
- W2587293770 hasConcept C2779161974 @default.
- W2587293770 hasConcept C2779612170 @default.
- W2587293770 hasConcept C2780868729 @default.
- W2587293770 hasConcept C42219234 @default.
- W2587293770 hasConcept C71924100 @default.
- W2587293770 hasConcept C89560881 @default.
- W2587293770 hasConceptScore W2587293770C126322002 @default.
- W2587293770 hasConceptScore W2587293770C141071460 @default.
- W2587293770 hasConceptScore W2587293770C159654299 @default.
- W2587293770 hasConceptScore W2587293770C164705383 @default.
- W2587293770 hasConceptScore W2587293770C203014093 @default.
- W2587293770 hasConceptScore W2587293770C2776301958 @default.
- W2587293770 hasConceptScore W2587293770C2776472838 @default.
- W2587293770 hasConceptScore W2587293770C2776710957 @default.
- W2587293770 hasConceptScore W2587293770C2777292125 @default.
- W2587293770 hasConceptScore W2587293770C2777557582 @default.
- W2587293770 hasConceptScore W2587293770C2778205648 @default.
- W2587293770 hasConceptScore W2587293770C2778810321 @default.
- W2587293770 hasConceptScore W2587293770C2778842783 @default.
- W2587293770 hasConceptScore W2587293770C2778881276 @default.
- W2587293770 hasConceptScore W2587293770C2779161974 @default.
- W2587293770 hasConceptScore W2587293770C2779612170 @default.
- W2587293770 hasConceptScore W2587293770C2780868729 @default.
- W2587293770 hasConceptScore W2587293770C42219234 @default.
- W2587293770 hasConceptScore W2587293770C71924100 @default.
- W2587293770 hasConceptScore W2587293770C89560881 @default.
- W2587293770 hasLocation W25872937701 @default.
- W2587293770 hasOpenAccess W2587293770 @default.
- W2587293770 hasPrimaryLocation W25872937701 @default.
- W2587293770 hasRelatedWork W1982196709 @default.
- W2587293770 hasRelatedWork W1994252458 @default.
- W2587293770 hasRelatedWork W1994357312 @default.
- W2587293770 hasRelatedWork W2005778820 @default.
- W2587293770 hasRelatedWork W2041058486 @default.
- W2587293770 hasRelatedWork W2052041588 @default.
- W2587293770 hasRelatedWork W2054631762 @default.
- W2587293770 hasRelatedWork W2091368006 @default.
- W2587293770 hasRelatedWork W2120144460 @default.
- W2587293770 hasRelatedWork W2127076371 @default.
- W2587293770 hasRelatedWork W2136668860 @default.
- W2587293770 hasRelatedWork W2140396249 @default.
- W2587293770 hasRelatedWork W2155167030 @default.
- W2587293770 hasRelatedWork W2170589528 @default.
- W2587293770 hasRelatedWork W2460913763 @default.
- W2587293770 hasRelatedWork W2468912166 @default.
- W2587293770 hasRelatedWork W2578209385 @default.
- W2587293770 hasRelatedWork W3009622834 @default.
- W2587293770 hasRelatedWork W3205917267 @default.
- W2587293770 hasRelatedWork W1973757215 @default.
- W2587293770 isParatext "false" @default.
- W2587293770 isRetracted "false" @default.
- W2587293770 magId "2587293770" @default.
- W2587293770 workType "article" @default.