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- W2587295890 abstract "PET (positron emission tomography) in vivo imaging of cerebral conformational diseases is essentially based on non-peptide small molecule ligands used to detect early alterations in peptide secondary structures and subsequent accumulation of aberrant oligomers and protein deposits involved in progressive neurodegeneration, cognitive and movement disorders. In this article, an overview is given about tracers currently available and lead structures of potential PET probes for detection of β-amyloid (Aβ), tau protein, α-synuclein, constitutive (PrPc) and infectious isoforms (PrPsc) of prions (proteinaceous infectious particles) as imaging targets. Whereas the styrylpyridine derivative florbetapir, approved for clinical applications, the stilbene derivative florbetaben and the benzoxazole derivative BF227 show high affinity binding to Aβ, preclinical investigations promise improved pharmacokinetics for benzoimidazothiazoles, aryloxazoles and benzofuran derivatives. Tau protein imaging based clinically, presently, on the pyridine-pyridoindole T807 has got new incentives following identification of a series of pyrrolopyridine quinolines and pharmacokinetic improvements of fluoropropoxy quinolines including for instance THK-5351. The pyridine isoquinoline MK6240 is involved now in clinical trials. Most forward-looking efforts apply to small molecule ligands of α-synuclein, which are expected to permit a breakthrough in differential diagnostics of Parkinson-related dementia and Lewy body diseases. However, at the moment the proposed lead structures are in affinity and blood brain barrier delivery properties below the possibilities of Aβ and tau protein ligands. This is the case also for potential tracers of prion proteins." @default.
- W2587295890 created "2017-02-17" @default.
- W2587295890 creator A5048282307 @default.
- W2587295890 date "2017-01-01" @default.
- W2587295890 modified "2023-10-18" @default.
- W2587295890 title "Small Molecule-Assisted PET: Approaches to Imaging of Conformational Diseases of the Brain" @default.
- W2587295890 cites W1493993231 @default.
- W2587295890 cites W1503393361 @default.
- W2587295890 cites W1526771916 @default.
- W2587295890 cites W1532763771 @default.
- W2587295890 cites W1536538075 @default.
- W2587295890 cites W1560882668 @default.
- W2587295890 cites W1733199444 @default.
- W2587295890 cites W1835478781 @default.
- W2587295890 cites W1959197363 @default.
- W2587295890 cites W1964976230 @default.
- W2587295890 cites W1965632005 @default.
- W2587295890 cites W1966196229 @default.
- W2587295890 cites W1969024078 @default.
- W2587295890 cites W1971804606 @default.
- W2587295890 cites W1975040221 @default.
- W2587295890 cites W1975224813 @default.
- W2587295890 cites W1976201852 @default.
- W2587295890 cites W1977682751 @default.
- W2587295890 cites W197927967 @default.
- W2587295890 cites W1980779214 @default.
- W2587295890 cites W1980825524 @default.
- W2587295890 cites W1984687162 @default.
- W2587295890 cites W1986837175 @default.
- W2587295890 cites W1987204546 @default.
- W2587295890 cites W1990438740 @default.
- W2587295890 cites W1991369110 @default.
- W2587295890 cites W1993160420 @default.
- W2587295890 cites W1995018488 @default.
- W2587295890 cites W2000703103 @default.
- W2587295890 cites W2000966016 @default.
- W2587295890 cites W2001445086 @default.
- W2587295890 cites W2007157911 @default.
- W2587295890 cites W2007377859 @default.
- W2587295890 cites W2009769139 @default.
- W2587295890 cites W2009870816 @default.
- W2587295890 cites W2015172719 @default.
- W2587295890 cites W2016193689 @default.
- W2587295890 cites W2016382834 @default.
- W2587295890 cites W2016575780 @default.
- W2587295890 cites W2017457068 @default.
- W2587295890 cites W2019261301 @default.
- W2587295890 cites W2019299951 @default.
- W2587295890 cites W2022176071 @default.
- W2587295890 cites W2022833698 @default.
- W2587295890 cites W2024940817 @default.
- W2587295890 cites W2028557939 @default.
- W2587295890 cites W2030368504 @default.
- W2587295890 cites W2032459438 @default.
- W2587295890 cites W2034075546 @default.
- W2587295890 cites W2034147064 @default.
- W2587295890 cites W2035192986 @default.
- W2587295890 cites W2035661230 @default.
- W2587295890 cites W2036282548 @default.
- W2587295890 cites W2036599501 @default.
- W2587295890 cites W2037473016 @default.
- W2587295890 cites W2044699444 @default.
- W2587295890 cites W2046093999 @default.
- W2587295890 cites W2046569445 @default.
- W2587295890 cites W2053349920 @default.
- W2587295890 cites W2053625282 @default.
- W2587295890 cites W2054504521 @default.
- W2587295890 cites W2055167776 @default.
- W2587295890 cites W2057244135 @default.
- W2587295890 cites W2059516728 @default.
- W2587295890 cites W2059804089 @default.
- W2587295890 cites W2064996887 @default.
- W2587295890 cites W2065622081 @default.
- W2587295890 cites W2066598200 @default.
- W2587295890 cites W2066601618 @default.
- W2587295890 cites W2066777346 @default.
- W2587295890 cites W2068578172 @default.
- W2587295890 cites W2069130915 @default.
- W2587295890 cites W2070056741 @default.
- W2587295890 cites W2072805367 @default.
- W2587295890 cites W2074082294 @default.
- W2587295890 cites W2074513890 @default.
- W2587295890 cites W2075503719 @default.
- W2587295890 cites W2076467891 @default.
- W2587295890 cites W2078326464 @default.
- W2587295890 cites W2080848024 @default.
- W2587295890 cites W2082184462 @default.
- W2587295890 cites W2082998566 @default.
- W2587295890 cites W2083630246 @default.
- W2587295890 cites W2085022941 @default.
- W2587295890 cites W2087243986 @default.
- W2587295890 cites W2088459134 @default.
- W2587295890 cites W2088493877 @default.
- W2587295890 cites W2093116184 @default.
- W2587295890 cites W2094483441 @default.
- W2587295890 cites W2096695700 @default.
- W2587295890 cites W2099795098 @default.
- W2587295890 cites W2104349121 @default.