FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587307788> ?p ?o ?g. }

• W2587307788 endingPage "555" @default.
• W2587307788 startingPage "549" @default.
• W2587307788 abstract "The ability to plan and execute appropriately timed responses to external stimuli is based on a well-orchestrated balance between movement initiation and inhibition. In impulse control disorders involving the prefrontal cortex (PFC) [1], this balance is disturbed, emphasizing the critical role that PFC plays in appropriately timing actions [2-4]. Here, we employed optogenetic and electrophysiological techniques to systematically analyze the functional role of five key subareas of the rat medial PFC (mPFC) and orbitofrontal cortex (OFC) in action control [5-9]. Inactivation of mPFC subareas induced drastic changes in performance, namely an increase (prelimbic cortex, PL) or decrease (infralimbic cortex, IL) of premature responses. Additionally, electrophysiology revealed a significant decrease in neuronal activity of a PL subpopulation prior to premature responses. In contrast, inhibition of OFC subareas (mainly the ventral OFC, i.e., VO) significantly impaired the ability to respond rapidly after external cues. Consistent with these findings, mPFC activity during response preparation predicted trial outcomes and reaction times significantly better than OFC activity. These data support the concept of opposing roles of IL and PL in directing proactive behavior and argue for an involvement of OFC in predominantly reactive movement control. By attributing defined roles to rodent PFC sections, this study contributes to a deeper understanding of the functional heterogeneity of this brain area and thus may guide medically relevant studies of PFC-associated impulse control disorders in this animal model for neural disorders [10-12]." @default.
• W2587307788 created "2017-02-17" @default.
• W2587307788 creator A5017967974 @default.
• W2587307788 creator A5020078905 @default.
• W2587307788 creator A5026142850 @default.
• W2587307788 creator A5037720828 @default.
• W2587307788 creator A5055681491 @default.
• W2587307788 creator A5065838842 @default.
• W2587307788 creator A5073635476 @default.
• W2587307788 creator A5075369706 @default.
• W2587307788 creator A5081500500 @default.
• W2587307788 date "2017-02-01" @default.
• W2587307788 modified "2023-10-12" @default.
• W2587307788 title "A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition" @default.
• W2587307788 cites W1969100427 @default.
• W2587307788 cites W1971246980 @default.
• W2587307788 cites W1986106151 @default.
• W2587307788 cites W1990208186 @default.
• W2587307788 cites W2000621650 @default.
• W2587307788 cites W2001488814 @default.
• W2587307788 cites W2004448205 @default.
• W2587307788 cites W2008098183 @default.
• W2587307788 cites W2009833394 @default.
• W2587307788 cites W2027616888 @default.
• W2587307788 cites W2028000911 @default.
• W2587307788 cites W2040527392 @default.
• W2587307788 cites W2042072274 @default.
• W2587307788 cites W2044575472 @default.
• W2587307788 cites W2056110254 @default.
• W2587307788 cites W2058215820 @default.
• W2587307788 cites W2066515711 @default.
• W2587307788 cites W2073626660 @default.
• W2587307788 cites W2080316356 @default.
• W2587307788 cites W2087129491 @default.
• W2587307788 cites W2087404956 @default.
• W2587307788 cites W2093533434 @default.
• W2587307788 cites W2107574028 @default.
• W2587307788 cites W2114770633 @default.
• W2587307788 cites W2118038184 @default.
• W2587307788 cites W2143885146 @default.
• W2587307788 cites W2155697728 @default.
• W2587307788 cites W2156001698 @default.
• W2587307788 cites W2157933061 @default.
• W2587307788 cites W2172252169 @default.
• W2587307788 doi "https://doi.org/10.1016/j.cub.2016.12.052" @default.
• W2587307788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28190729" @default.
• W2587307788 hasPublicationYear "2017" @default.
• W2587307788 type Work @default.
• W2587307788 sameAs 2587307788 @default.
• W2587307788 citedByCount "89" @default.
• W2587307788 countsByYear W25873077882017 @default.
• W2587307788 countsByYear W25873077882018 @default.
• W2587307788 countsByYear W25873077882019 @default.
• W2587307788 countsByYear W25873077882020 @default.
• W2587307788 countsByYear W25873077882021 @default.
• W2587307788 countsByYear W25873077882022 @default.
• W2587307788 countsByYear W25873077882023 @default.
• W2587307788 crossrefType "journal-article" @default.
• W2587307788 hasAuthorship W2587307788A5017967974 @default.
• W2587307788 hasAuthorship W2587307788A5020078905 @default.
• W2587307788 hasAuthorship W2587307788A5026142850 @default.
• W2587307788 hasAuthorship W2587307788A5037720828 @default.
• W2587307788 hasAuthorship W2587307788A5055681491 @default.
• W2587307788 hasAuthorship W2587307788A5065838842 @default.
• W2587307788 hasAuthorship W2587307788A5073635476 @default.
• W2587307788 hasAuthorship W2587307788A5075369706 @default.
• W2587307788 hasAuthorship W2587307788A5081500500 @default.
• W2587307788 hasBestOaLocation W25873077881 @default.
• W2587307788 hasConcept C169760540 @default.
• W2587307788 hasConcept C169900460 @default.
• W2587307788 hasConcept C185263204 @default.
• W2587307788 hasConcept C2776559556 @default.
• W2587307788 hasConcept C2779934784 @default.
• W2587307788 hasConcept C2781195155 @default.
• W2587307788 hasConcept C50738837 @default.
• W2587307788 hasConcept C86803240 @default.
• W2587307788 hasConceptScore W2587307788C169760540 @default.
• W2587307788 hasConceptScore W2587307788C169900460 @default.
• W2587307788 hasConceptScore W2587307788C185263204 @default.
• W2587307788 hasConceptScore W2587307788C2776559556 @default.
• W2587307788 hasConceptScore W2587307788C2779934784 @default.
• W2587307788 hasConceptScore W2587307788C2781195155 @default.
• W2587307788 hasConceptScore W2587307788C50738837 @default.
• W2587307788 hasConceptScore W2587307788C86803240 @default.
• W2587307788 hasFunder F4320321114 @default.
• W2587307788 hasIssue "4" @default.
• W2587307788 hasLocation W25873077881 @default.
• W2587307788 hasLocation W25873077882 @default.
• W2587307788 hasOpenAccess W2587307788 @default.
• W2587307788 hasPrimaryLocation W25873077881 @default.
• W2587307788 hasRelatedWork W2064366652 @default.
• W2587307788 hasRelatedWork W2106057704 @default.
• W2587307788 hasRelatedWork W2587307788 @default.
• W2587307788 hasRelatedWork W2614568700 @default.
• W2587307788 hasRelatedWork W2803095608 @default.
• W2587307788 hasRelatedWork W3182241891 @default.
• W2587307788 hasRelatedWork W4200226383 @default.
• W2587307788 hasRelatedWork W4213064528 @default.

• next