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- W2587310367 abstract "The regulation of adipose tissue expansion by adipocyte hypertrophy and/or hyperplasia is the topic of extensive investigations given the potential differential contribution of the 2 processes to the development of numerous chronic diseases associated with obesity. We recently discovered that the loss-of-function of the Src homology domain-containing protein Nck2 in mice promotes adiposity accompanied with adipocyte hypertrophy and impaired function, and enhanced adipocyte differentiation in vitro. Moreover, in severely-obese human's adipose tissue, we found that Nck2 expression is markedly downregulated. In this commentary, our goal is to expand upon additional findings providing further evidence for a unique Nck2-dependent mechanism regulating adipogenesis. We propose that Nck2 should be further investigated as a regulator of the reliance of white adipose tissue on hyperplasia versus hypertrophy during adipose tissue expansion, and hence, as a potential novel molecular target in obesity." @default.
- W2587310367 created "2017-02-17" @default.
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- W2587310367 date "2017-02-06" @default.
- W2587310367 modified "2023-09-23" @default.
- W2587310367 title "Nck2, an unexpected regulator of adipogenesis" @default.
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- W2587310367 doi "https://doi.org/10.1080/21623945.2017.1291102" @default.
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