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- W2587331330 abstract "Effective number of codons (N^c) and its variant N^'c (effective number of codons prime) are the two widely used methods for measuring unequal usage of synonymous codons in coding sequences, known as the codon usage bias (CUB). The mathematical formula used in calculating N^c and N^'c values is giving inappropriate measures of CUB in case of low abundance of amino acids. In addition, the magnitude of error also varies according to codon degeneracy. In this study, a modified formula for N^c and N^'c has been developed to measure the CUB more accurately. Online implementations of the modified formula are available in the web portal at http://agnigarh.tezu.ernet.in/~ssankar/cub.php." @default.
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- W2587331330 date "2017-02-10" @default.
- W2587331330 modified "2023-09-25" @default.
- W2587331330 title "Codon degeneracy and amino acid abundance influence the measures of codon usage bias: improved Nc (<i>N̂<sub>c</sub></i>) and ENCprime (<i>N̂<sup>′</sup><sub>c</sub></i>) measures" @default.
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- W2587331330 doi "https://doi.org/10.1111/gtc.12474" @default.
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