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• W2587357328 abstract "421 We have previously shown that clofarabine radiosensitizes DLD-1 colon tumor xenografts (Proc. Amer. Assoc. Cancer Res. 48: 1196). The purpose of the current study was to determine whether other tumor xenograft histiotypes can be radiosensitized by clofarabine. Gemcitabine was used as a comparison for radiosensitization in all studies. We investigated six other xenograft models: NCI-H460 lung, SR475HN head and neck, SF-295 glioblastoma, DU-145 prostate, PANC-1 pancreatic, and HCT-116 colon. Mice were implanted with tumor fragments subcutaneously from an in vivo passage and the tumors were allowed to grow. Mice with tumors in the designated size range were selected for the studies. The NCI-H460 and SF-295 studies used 12 Gy total radiation delivered in four, 3 Gy fractions every three days combined with clofarabine injected by intraperitoneal (ip) injection daily for 10 days at a dosage of 30 mg/kg/injection. The remaining tumor models were given 20 Gy, in 2 Gy fractions daily for five days for two weeks combined with clofarabine injected ip daily for 12 days at a dosage of 30 mg/kg/injection. Clofarabine had no effect on the growth of SF-295 glioblastoma which was not enhanced by radiation. There was no difference between radiation alone and radiation combined with clofarabine in DU-145 prostate xenografts. The combined effect on NCI-H460 lung tumors appeared to be additive with T-C values (based on time to 3 tumor doublings) of 4.6, 9.4, and 16.9 days for clofarabine, radiation, and the combination, respectively. SR475HN head and neck tumors were radiosensitized by clofarabine with T-C values (based on 2 tumor doublings) of 16.7, 73.2, and >162 days for clofarabine, radiation, and the combination, respectively. PANC-1 pancreatic tumors were radiosensitized by clofarabine with T-C values (based on 2 tumor doublings) of 17.2, 1.7, and 62.9 days for clofarabine, radiation, and the combination, respectively. HCT-116 colon tumors were radiosensitized by clofarabine with T-C values (based on 3 tumor doublings) of 24.2, 29.3, and >78.9 days for clofarabine, radiation, and the combination, respectively. The radiosensitizing capacity of gemcitabine tracked with the clofarabine results. Three out of the six tumor models tested showed marked radiosensitization with clofarabine while another tumor model showed an additive effect. Two out of the six models tested showed no evidence of an interaction between clofarabine and radiation. Clofarabine has potential as a radiosensitizing cancer treatment." @default.
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• W2587357328 date "2008-05-01" @default.
• W2587357328 modified "2023-09-28" @default.
• W2587357328 title "Evaluation of the radiosensitizing potential of clofarabine in six xenograft models." @default.
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