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- W2587361618 abstract "Background Uterineendometrialcancerisclassifiedintotwogroups:type1,which includes grades 1 and 2 endometrial carcinoma; and type 2, which includes grade 3 endometrial carcinoma, serous adenocarcinoma, clear cell carcinoma, and mucinous carcinoma. No studies assessing optimal surveillance after initial treatment for endometrial cancer have been performed. This study aimed to determine the association between cancer type and recurrence time as well as the effect ofprognostic factors. Methods Charts for patients with endometrial cancer who underwentsurgerybetween January 2005 and December 2011 were retrospectively reviewed, and clinicopathological features and clinical courses were compared between patients with type 1 and type 2 disease. Cumulative incidence curves for recurrence were estimated, and the association between the time ofrelapse and cancer type was assessed by multivariate logistic regression. Results Three hundred seventeen patients with type 1 disease and 106 patients with type 2 disease were evaluable. Advanced stage (stage III or IV) was more commonly foundamongpatients with type 2 endometrial cancer (12% vs. 30.2%, p < 0.05). Progression-freesurvivalwassignificantlyworseinpatientswithtype2disease,andit was also worse in patients with early stage disease. Type 2 diagnosis was an independent poorprognosticfactorofpoorprogression-freesurvivalanddisease-specificsurvivalby multivariate Cox regression analysis. The 2-year and 5-year recurrence rates in patients with type 1 disease were 3% and 8%, while the rates in patients with type 2 disease were 25%and30%,respectively.Almostallpatientswithtype2diseaseexperienced recurrence within 2 years. Conclusions Type 2 ofendometrial cancer recurred earlier than type 1 disease. More careful surveillance after initial treatment is needed for patients with type 2 endometrial cancer, especially in the first 2 years. Legal entity responsible for the study N/A Funding N/A Disclosure All authors have declared no conflicts ofinterest." @default.
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- W2587361618 date "2016-12-01" @default.
- W2587361618 modified "2023-09-30" @default.
- W2587361618 title "321P Clinical course comparison between patients with type 1 and type 2 uterine endometrial cancers" @default.
- W2587361618 doi "https://doi.org/10.1016/s0923-7534(21)00479-8" @default.
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