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- W2587375458 abstract "The pathogenesis of cholesterol gallstones in women, especially during the childbearing years, and in association with the administration of female sex hormones, is a major interest of our research group. Studies in several laboratories, including ours, have revealed an increase in biliary cholesterol saturation and secretion in pregnant women and in those exposed to birth control pills. The physiological and biochemical mechanisms responsible for this relative increase in cholesterol in the bile are not understood. A list of possible mechanisms, probably an incomplete one, is shown in Table 6.1. We are currently studying several of them. Increased cholesterol secretion due to altered secretory coupling of biliary lipids, secondary to an increase in the ratio of biliary cholic (CA) to cheno deoxycholic acid (CDCA) is one of the areas of special interest. The purpose of this paper is to briefly review the relevant data, to assess their possible importance and to present preliminary results of current studies. Bennion and colleagues reported that in prepubertal and immediately post pubertal American Indian boys and girls, there was no sex difference in bile acid composition!, but in a separate study of Indian and Caucasian adults, Table 6.1 Possible mechanisms of female sex hormone-induced increase in biliary cholesterol" @default.
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- W2587375458 date "1985-01-01" @default.
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- W2587375458 title "6 Effect of female sex hormones on bi Ie acids" @default.
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