FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587397868> ?p ?o ?g. }

• W2587397868 endingPage "969" @default.
• W2587397868 startingPage "961" @default.
• W2587397868 abstract "To assess the utility of serum neurofilament for diagnosis and monitoring of primary progressive aphasia (PPA) variants.We investigated neurofilament light chain (NF-L) levels in blood of 99 patients with PPA (40 with nonfluent variant PPA [nfvPPA], 38 with semantic variant PPA [svPPA], 21 with logopenic variant PPA [lvPPA]) and compared diagnostic performance with that reached by CSF NF-L, phosphorylated neurofilament heavy chain (pNF-H), β-amyloid (Aβ1-42), tau, and phosphorylated tau. The longitudinal change of blood NF-L levels was measured and analyzed for correlation with functional decline and brain atrophy.Serum NF-L is increased in PPA compared to controls and discriminates between nfvPPA/svPPA and lvPPA with 81% sensitivity and 67% specificity (cutoff 31 pg/mL). CSF NF-L, pNF-H, tau, phosphorylated tau, and Aβ1-42 achieved similar performance, and pNF-H was the only marker for discrimination of nfvPPA from svPPA/lvPPA. In most patients with nfvPPA and svPPA, but not lvPPA, serum NF-L increased within follow-up. The increase correlated with functional decline and progression of atrophy of the left frontal lobe of all patients with PPAs and the right middle frontal gyrus of patients with nfvPPA and svPPA.Blood level of NF-L can aid the differential diagnosis of PPA variants, especially in combination with CSF pNF-H. Because serum NF-L correlates with functional decline and atrophy in the disease course, it qualifies as an objective disease status marker. Extended follow-up studies with cases of known neuropathology are imperative.This study provides Class I evidence that in patients with PPA, blood levels of NF-L can distinguish the logopenic variant from the nonfluent/agrammatic and semantic variants." @default.
• W2587397868 created "2017-02-17" @default.
• W2587397868 creator A5008189468 @default.
• W2587397868 creator A5008484351 @default.
• W2587397868 creator A5014117021 @default.
• W2587397868 creator A5019098128 @default.
• W2587397868 creator A5021070522 @default.
• W2587397868 creator A5045258788 @default.
• W2587397868 creator A5050028517 @default.
• W2587397868 creator A5050058929 @default.
• W2587397868 creator A5067913949 @default.
• W2587397868 creator A5068163463 @default.
• W2587397868 creator A5071062652 @default.
• W2587397868 creator A5071308068 @default.
• W2587397868 creator A5076150165 @default.
• W2587397868 creator A5076331208 @default.
• W2587397868 creator A5077075965 @default.
• W2587397868 creator A5077112670 @default.
• W2587397868 creator A5080821885 @default.
• W2587397868 creator A5084389843 @default.
• W2587397868 creator A5086343406 @default.
• W2587397868 creator A5086649068 @default.
• W2587397868 creator A5089555874 @default.
• W2587397868 creator A5090410744 @default.
• W2587397868 creator A5091400473 @default.
• W2587397868 date "2017-02-08" @default.
• W2587397868 modified "2023-09-26" @default.
• W2587397868 title "Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias" @default.
• W2587397868 cites W1528949696 @default.
• W2587397868 cites W1553615263 @default.
• W2587397868 cites W1847168837 @default.
• W2587397868 cites W1927582128 @default.
• W2587397868 cites W1965278136 @default.
• W2587397868 cites W1984148891 @default.
• W2587397868 cites W1991952617 @default.
• W2587397868 cites W1995139137 @default.
• W2587397868 cites W2018004016 @default.
• W2587397868 cites W2040880523 @default.
• W2587397868 cites W2056196309 @default.
• W2587397868 cites W2070458400 @default.
• W2587397868 cites W2083054399 @default.
• W2587397868 cites W2083099567 @default.
• W2587397868 cites W2090330337 @default.
• W2587397868 cites W2092693001 @default.
• W2587397868 cites W2106279576 @default.
• W2587397868 cites W2107099006 @default.
• W2587397868 cites W2130519776 @default.
• W2587397868 cites W2133054185 @default.
• W2587397868 cites W2134323711 @default.
• W2587397868 cites W2136911505 @default.
• W2587397868 cites W2138190873 @default.
• W2587397868 cites W2141909536 @default.
• W2587397868 cites W2151439085 @default.
• W2587397868 cites W2157203036 @default.
• W2587397868 cites W2165934826 @default.
• W2587397868 cites W2202991984 @default.
• W2587397868 cites W2225755951 @default.
• W2587397868 cites W2283930528 @default.
• W2587397868 cites W2302353779 @default.
• W2587397868 cites W2306559597 @default.
• W2587397868 cites W2342233016 @default.
• W2587397868 cites W2404568684 @default.
• W2587397868 cites W2418840920 @default.
• W2587397868 cites W2485231799 @default.
• W2587397868 cites W2495647680 @default.
• W2587397868 cites W2511591175 @default.
• W2587397868 doi "https://doi.org/10.1212/wnl.0000000000003688" @default.
• W2587397868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28179468" @default.
• W2587397868 hasPublicationYear "2017" @default.
• W2587397868 type Work @default.
• W2587397868 sameAs 2587397868 @default.
• W2587397868 citedByCount "68" @default.
• W2587397868 countsByYear W25873978682017 @default.
• W2587397868 countsByYear W25873978682018 @default.
• W2587397868 countsByYear W25873978682019 @default.
• W2587397868 countsByYear W25873978682020 @default.
• W2587397868 countsByYear W25873978682021 @default.
• W2587397868 countsByYear W25873978682022 @default.
• W2587397868 countsByYear W25873978682023 @default.
• W2587397868 crossrefType "journal-article" @default.
• W2587397868 hasAuthorship W2587397868A5008189468 @default.
• W2587397868 hasAuthorship W2587397868A5008484351 @default.
• W2587397868 hasAuthorship W2587397868A5014117021 @default.
• W2587397868 hasAuthorship W2587397868A5019098128 @default.
• W2587397868 hasAuthorship W2587397868A5021070522 @default.
• W2587397868 hasAuthorship W2587397868A5045258788 @default.
• W2587397868 hasAuthorship W2587397868A5050028517 @default.
• W2587397868 hasAuthorship W2587397868A5050058929 @default.
• W2587397868 hasAuthorship W2587397868A5067913949 @default.
• W2587397868 hasAuthorship W2587397868A5068163463 @default.
• W2587397868 hasAuthorship W2587397868A5071062652 @default.
• W2587397868 hasAuthorship W2587397868A5071308068 @default.
• W2587397868 hasAuthorship W2587397868A5076150165 @default.
• W2587397868 hasAuthorship W2587397868A5076331208 @default.
• W2587397868 hasAuthorship W2587397868A5077075965 @default.
• W2587397868 hasAuthorship W2587397868A5077112670 @default.
• W2587397868 hasAuthorship W2587397868A5080821885 @default.
• W2587397868 hasAuthorship W2587397868A5084389843 @default.

• next