Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587614615> ?p ?o ?g. }
- W2587614615 endingPage "1915" @default.
- W2587614615 startingPage "1903" @default.
- W2587614615 abstract "High-risk neuroblastoma is characterized by undifferentiated neuroblasts and low schwannian stroma content. The tumor stroma contributes to the suppression of tumor growth by releasing soluble factors that promote neuroblast differentiation. Here we identify heparin-binding epidermal growth factor–like growth factor (HBEGF) as a potent prodifferentiating factor in neuroblastoma. HBEGF mRNA expression is decreased in human neuroblastoma tumors compared with benign tumors, with loss correlating with decreased survival. HBEGF protein is expressed only in stromal compartments of human neuroblastoma specimens, with tissue from high-stage disease containing very little stroma or HBEGF expression. In 3 human neuroblastoma cell lines (SK-N-AS, SK-N-BE2, and SH-SY5Y), soluble HBEGF is sufficient to promote neuroblast differentiation and decrease proliferation. Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor, leading to activation of the ERK1/2 and STAT3 pathways and up-regulation of the inhibitor of DNA binding transcription factor. These data support a role for loss of HBEGF in the neuroblastoma tumor microenvironment in neuroblastoma pathogenesis.—Gaviglio, A. L., Knelson, E. H., Blobe, G. C. Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation. FASEB J. 31, 1903–1915 (2017). www.fasebj.org" @default.
- W2587614615 created "2017-02-17" @default.
- W2587614615 creator A5005440027 @default.
- W2587614615 creator A5029870390 @default.
- W2587614615 creator A5051899028 @default.
- W2587614615 date "2017-02-07" @default.
- W2587614615 modified "2023-10-12" @default.
- W2587614615 title "Heparin‐binding epidermal growth factor‐like growth factor promotes neuroblastoma differentiation" @default.
- W2587614615 cites W1514034386 @default.
- W2587614615 cites W1636784964 @default.
- W2587614615 cites W1715855743 @default.
- W2587614615 cites W179748458 @default.
- W2587614615 cites W1969785980 @default.
- W2587614615 cites W1970878854 @default.
- W2587614615 cites W1972346918 @default.
- W2587614615 cites W1978439333 @default.
- W2587614615 cites W1986157775 @default.
- W2587614615 cites W1986441249 @default.
- W2587614615 cites W1989996002 @default.
- W2587614615 cites W1990489847 @default.
- W2587614615 cites W1993553506 @default.
- W2587614615 cites W2011039855 @default.
- W2587614615 cites W2014139160 @default.
- W2587614615 cites W2014463647 @default.
- W2587614615 cites W2015812392 @default.
- W2587614615 cites W2023803160 @default.
- W2587614615 cites W2024234796 @default.
- W2587614615 cites W2028101194 @default.
- W2587614615 cites W2028871894 @default.
- W2587614615 cites W2037920183 @default.
- W2587614615 cites W2046982555 @default.
- W2587614615 cites W2049165350 @default.
- W2587614615 cites W2059226282 @default.
- W2587614615 cites W2060165468 @default.
- W2587614615 cites W2061164422 @default.
- W2587614615 cites W2064397275 @default.
- W2587614615 cites W2065367452 @default.
- W2587614615 cites W2067188105 @default.
- W2587614615 cites W2076672895 @default.
- W2587614615 cites W2083941386 @default.
- W2587614615 cites W2086121306 @default.
- W2587614615 cites W2086603527 @default.
- W2587614615 cites W2090206486 @default.
- W2587614615 cites W2091061874 @default.
- W2587614615 cites W2101851382 @default.
- W2587614615 cites W2103359202 @default.
- W2587614615 cites W2104831072 @default.
- W2587614615 cites W2106663496 @default.
- W2587614615 cites W2110941920 @default.
- W2587614615 cites W2112818390 @default.
- W2587614615 cites W2114460712 @default.
- W2587614615 cites W2116715149 @default.
- W2587614615 cites W2117222458 @default.
- W2587614615 cites W2118517346 @default.
- W2587614615 cites W2120331067 @default.
- W2587614615 cites W2121076016 @default.
- W2587614615 cites W2122687697 @default.
- W2587614615 cites W2122826790 @default.
- W2587614615 cites W2124806986 @default.
- W2587614615 cites W2128094338 @default.
- W2587614615 cites W2128824536 @default.
- W2587614615 cites W2130925781 @default.
- W2587614615 cites W2136419196 @default.
- W2587614615 cites W2138805078 @default.
- W2587614615 cites W2143250882 @default.
- W2587614615 cites W2147457741 @default.
- W2587614615 cites W2151876471 @default.
- W2587614615 cites W2151962695 @default.
- W2587614615 cites W2152512826 @default.
- W2587614615 cites W2159041180 @default.
- W2587614615 cites W2162034426 @default.
- W2587614615 cites W2169931542 @default.
- W2587614615 cites W2327522594 @default.
- W2587614615 cites W4211031423 @default.
- W2587614615 cites W4241801284 @default.
- W2587614615 cites W4376849078 @default.
- W2587614615 doi "https://doi.org/10.1096/fj.201600828r" @default.
- W2587614615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5388552" @default.
- W2587614615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28174207" @default.
- W2587614615 hasPublicationYear "2017" @default.
- W2587614615 type Work @default.
- W2587614615 sameAs 2587614615 @default.
- W2587614615 citedByCount "13" @default.
- W2587614615 countsByYear W25876146152017 @default.
- W2587614615 countsByYear W25876146152018 @default.
- W2587614615 countsByYear W25876146152019 @default.
- W2587614615 countsByYear W25876146152020 @default.
- W2587614615 countsByYear W25876146152021 @default.
- W2587614615 countsByYear W25876146152022 @default.
- W2587614615 countsByYear W25876146152023 @default.
- W2587614615 crossrefType "journal-article" @default.
- W2587614615 hasAuthorship W2587614615A5005440027 @default.
- W2587614615 hasAuthorship W2587614615A5029870390 @default.
- W2587614615 hasAuthorship W2587614615A5051899028 @default.
- W2587614615 hasBestOaLocation W25876146151 @default.
- W2587614615 hasConcept C126322002 @default.
- W2587614615 hasConcept C134018914 @default.
- W2587614615 hasConcept C16930146 @default.