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• W2587640215 endingPage "119" @default.
• W2587640215 startingPage "108" @default.
• W2587640215 abstract "Merkel cell carcinoma (MCC) is a rare, highly aggressive tumor, and local or regional disease recurrence is common, as is metastasis. MCC usually develops in sun-exposed skin in patients of advanced age. Its incidence has risen 4-fold in recent decades as the population has aged and immunohistochemical techniques have led to more diagnoses. The pathogenesis of MCC remains unclear but UV radiation, immunosuppression, and the presence of Merkel cell polyomavirus in the tumor genome seem to play key roles. This review seeks to update our understanding of the epidemiology, etiology, pathogenesis, and clinical features of MCC. We also review histologic and immunohistochemical features required for diagnosis. MCC staging is discussed, given its great importance in establishing a prognosis for these patients." @default.
• W2587640215 created "2017-02-17" @default.
• W2587640215 creator A5029134129 @default.
• W2587640215 creator A5034294573 @default.
• W2587640215 creator A5074491220 @default.
• W2587640215 date "2017-03-01" @default.
• W2587640215 modified "2023-09-23" @default.
• W2587640215 title "Update on Merkel Cell Carcinoma: Epidemiology, Etiopathogenesis, Clinical Features, Diagnosis, and Staging" @default.
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• W2587640215 doi "https://doi.org/10.1016/j.adengl.2016.12.004" @default.
• W2587640215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27770997" @default.

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