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- W2587646870 abstract "Background and Objectives: We have previously demonstrated the efficacy of a non-invasive, non-contact, fast andsimple but robust fluorescence imaging (u-FEI) method to monitor the healing of skin wounds in vitro. This system canimage highly-proliferating cellular processes (295/340 nm excitation/emission wavelengths) to study epithelialization ina cultured wound model. The objective of the current work is to evaluate the suitability of u-FEI for monitoring woundre-epithelialization in vivo.Study Design: Full-thickness wounds were created in the tail of rats and imaged weekly using u-FEI at 295/340nmexcitation/emission wavelengths. Histology was used to investigate the correlation between the spatial distribution andintensity of fluorescence and the extent of wound epithelialization. In addition, the expression of the nuclear proteinKi67 was used to confirm the association between the proliferation of keratinocyte cells and the intensity offluorescence.Results: Keratinocytes forming neo-epidermis exhibited higher fluorescence intensity than the keratinocytes notinvolved in re-epithelialization. In full-thickness wounds the fluorescence first appeared at the wound edge wherekeratinocytes initiated the epithelialization process. Fluorescence intensity increased towards the center as thekeratinocytes partially covered the wound. As the wound healed, fluorescence decreased at the edges and was presentonly at the center as the keratinocytes completely covered the wound at day 21. Histology demonstrated that changes influorescence intensity from the 295/340nm band corresponded to newly formed epidermis.Conclusions: u-FEI at 295/340nm allows visualization of proliferating keratinocyte cells during re-epithelialization ofwounds in vivo, potentially providing a quantitative, objective and simple method for evaluating wound closure in theclinic." @default.
- W2587646870 created "2017-02-17" @default.
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- W2587646870 date "2017-02-06" @default.
- W2587646870 modified "2023-09-23" @default.
- W2587646870 title "In vivo assessment of wound re-epithelialization by UV fluorescence excitation imaging" @default.
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- W2587646870 doi "https://doi.org/10.1117/12.2253934" @default.
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