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• W2587662302 endingPage "e0171719" @default.
• W2587662302 startingPage "e0171719" @default.
• W2587662302 abstract "Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental pollutant used worldwide as a plasticizer and solvent in many formulations. Based on available toxicological data, it has been classified as toxic for reproduction and as an endocrine disruptor. Despite this, ecotoxicological studies in aquatic wildlife organisms are still scarce. In the present work, the toxic molecular alterations caused by DEHP in aquatic larvae of the midge Chironomus riparius have been studied, by analyzing the transcriptional activity of genes related to some vital cellular pathways, such as the ribosomal machinery (rpL4, rpL13), the cell stress response (hsc70, hsp70, hsp40, hsp27), the ecdysone hormone pathway (EcR), the energy metabolism (GAPDH), and detoxication processes (CYP4G). Environmentally relevant concentrations (10-3 to 105 μg/L) and exposure conditions (24 to 96 h) have been tested, as well as the toxic effects after DEHP withdrawal. Although the compound caused no mortality, significant changes were detected in almost all the studied biomarkers: e.g. strong repression of hsp70; general inhibition of EcR; GAPDH activity loss in long exposures; among others. Our data show a general transcriptional downregulation that could be associated with an adaptive response to cell damage. Besides, the activity of the compound as an ecdysone antagonist and its delayed effects over almost all the biomarkers analyzed are described as novel toxic targets in insects." @default.
• W2587662302 created "2017-02-17" @default.
• W2587662302 creator A5027382737 @default.
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• W2587662302 date "2017-02-06" @default.
• W2587662302 modified "2023-10-18" @default.
• W2587662302 title "Transcriptional deregulation of genetic biomarkers in Chironomus riparius larvae exposed to ecologically relevant concentrations of di(2-ethylhexyl) phthalate (DEHP)" @default.
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• W2587662302 doi "https://doi.org/10.1371/journal.pone.0171719" @default.
• W2587662302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5293269" @default.
• W2587662302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28166271" @default.
• W2587662302 hasPublicationYear "2017" @default.
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