FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587669506> ?p ?o ?g. }

• W2587669506 abstract "Abstract Transfusion therapy for treatment of sickle cell disease (SCD) is predicted to increase, following the significant benefit of chronic red cell transfusion demonstrated by the stroke prevention trial (STOP). Despite progress in mitigating negative effects of transfusion therapy with the use of iron chelating agents, alloimmunization remains a significant problem. Patients with SCD have a higher incidence of antibody production compared to other patient groups undergoing chronic transfusion. To limit alloimmunization, many programs transfuse SCD patients with RBCs that are phenotype-matched for the most immunogenic blood groups, Rh and K, and some programs also supply RBCs from African-American (AA) donors. Although this approach reduces the incidence of alloantibody production, it is resource- and cost-prohibitive for many programs, and, importantly, some patients (∼5%) still become alloimmunized. The development of high-throughput genotyping for blood group antigens will make antigen-matching cost effective; therefore, it is important to determine why some patients become alloimmunized despite antigen-matching. We investigated the antibody specificity and sequenced the RH genes in 46 SCD patients who were alloimmunized, despite having received Rh and K matched units. The antibodies identified included anti-D, or -C, or -e, and/or antibodies to high-prevalence antigens. None had anti-E. RH gene sequencing revealed that 20 patients had a RHD-CE(3–7)-D hybrid gene in which RHD exons 3 through 7 are replaced with reciprocal exons from RHCE. The resulting Rh protein encodes an altered C antigen. This D-CE-D gene was also linked to an RHce allele encoding altered e antigen. These patients had anti-C and/or anti-e in their serum (i.e.-hrB). We screened healthy AA donors and found that the prevalence of the hybrid RHD-CE(3–7)-D gene in this population is 5–8%. The remaining 26 patients were homozygous for mutations in RHce and had produced anti-e, and some also had mutations in RHD and had produced anti-D. These results suggest that inheritance of a RHD-CE-D gene or altered RHce, with or without altered RHD, underlies Rh alloimmunization in SCD. The altered Rh proteins are not distinguished with current serologic typing reagents. Therefore, these patients are not truly Rh antigen matched. The development of RH genotyping platforms offers a potential solution to prevent alloimmunization by identifying SCD patients who are homozygous for variant alleles and at risk for production of alloantibodies to Rh antigens. The 5–8% of donor units with the same RH genotype could be directed to these high risk patients." @default.
• W2587669506 created "2017-02-17" @default.
• W2587669506 creator A5028816656 @default.
• W2587669506 creator A5036130090 @default.
• W2587669506 date "2007-11-16" @default.
• W2587669506 modified "2023-09-30" @default.
• W2587669506 title "RH Gene Polymorphisms Are Risk Factor for Alloimmunization in Patients with Sickle Cell Disease." @default.
• W2587669506 doi "https://doi.org/10.1182/blood.v110.11.455.455" @default.
• W2587669506 hasPublicationYear "2007" @default.
• W2587669506 type Work @default.
• W2587669506 sameAs 2587669506 @default.
• W2587669506 citedByCount "1" @default.
• W2587669506 crossrefType "journal-article" @default.
• W2587669506 hasAuthorship W2587669506A5028816656 @default.
• W2587669506 hasAuthorship W2587669506A5036130090 @default.
• W2587669506 hasConcept C104317684 @default.
• W2587669506 hasConcept C120665830 @default.
• W2587669506 hasConcept C121332964 @default.
• W2587669506 hasConcept C121857725 @default.
• W2587669506 hasConcept C126322002 @default.
• W2587669506 hasConcept C135763542 @default.
• W2587669506 hasConcept C147483822 @default.
• W2587669506 hasConcept C159654299 @default.
• W2587669506 hasConcept C180754005 @default.
• W2587669506 hasConcept C203014093 @default.
• W2587669506 hasConcept C2778430493 @default.
• W2587669506 hasConcept C2779134260 @default.
• W2587669506 hasConcept C2779817106 @default.
• W2587669506 hasConcept C2780014101 @default.
• W2587669506 hasConcept C31467283 @default.
• W2587669506 hasConcept C54355233 @default.
• W2587669506 hasConcept C61511704 @default.
• W2587669506 hasConcept C71924100 @default.
• W2587669506 hasConcept C86803240 @default.
• W2587669506 hasConceptScore W2587669506C104317684 @default.
• W2587669506 hasConceptScore W2587669506C120665830 @default.
• W2587669506 hasConceptScore W2587669506C121332964 @default.
• W2587669506 hasConceptScore W2587669506C121857725 @default.
• W2587669506 hasConceptScore W2587669506C126322002 @default.
• W2587669506 hasConceptScore W2587669506C135763542 @default.
• W2587669506 hasConceptScore W2587669506C147483822 @default.
• W2587669506 hasConceptScore W2587669506C159654299 @default.
• W2587669506 hasConceptScore W2587669506C180754005 @default.
• W2587669506 hasConceptScore W2587669506C203014093 @default.
• W2587669506 hasConceptScore W2587669506C2778430493 @default.
• W2587669506 hasConceptScore W2587669506C2779134260 @default.
• W2587669506 hasConceptScore W2587669506C2779817106 @default.
• W2587669506 hasConceptScore W2587669506C2780014101 @default.
• W2587669506 hasConceptScore W2587669506C31467283 @default.
• W2587669506 hasConceptScore W2587669506C54355233 @default.
• W2587669506 hasConceptScore W2587669506C61511704 @default.
• W2587669506 hasConceptScore W2587669506C71924100 @default.
• W2587669506 hasConceptScore W2587669506C86803240 @default.
• W2587669506 hasLocation W25876695061 @default.
• W2587669506 hasOpenAccess W2587669506 @default.
• W2587669506 hasPrimaryLocation W25876695061 @default.
• W2587669506 hasRelatedWork W2040191638 @default.
• W2587669506 hasRelatedWork W2095498323 @default.
• W2587669506 hasRelatedWork W2102909757 @default.
• W2587669506 hasRelatedWork W2321201228 @default.
• W2587669506 hasRelatedWork W2335807561 @default.
• W2587669506 hasRelatedWork W2382016151 @default.
• W2587669506 hasRelatedWork W2382874770 @default.
• W2587669506 hasRelatedWork W2396932098 @default.
• W2587669506 hasRelatedWork W2590813347 @default.
• W2587669506 hasRelatedWork W4254778895 @default.
• W2587669506 isParatext "false" @default.
• W2587669506 isRetracted "false" @default.
• W2587669506 magId "2587669506" @default.
• W2587669506 workType "article" @default.