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• W2587691649 endingPage "740" @default.
• W2587691649 startingPage "724" @default.
• W2587691649 abstract "Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can serve as a powerful new class of cancer therapeutics. Clinical experience has helped to define the major challenges that must be met to make engineered T cells a reliable, safe, and effective platform that can be deployed against a broad range of tumors. The emergence of synthetic biology approaches for cellular engineering is providing us with a broadly expanded set of tools for programming immune cells. We discuss how these tools could be used to design the next generation of smart T cell precision therapeutics. Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can serve as a powerful new class of cancer therapeutics. Clinical experience has helped to define the major challenges that must be met to make engineered T cells a reliable, safe, and effective platform that can be deployed against a broad range of tumors. The emergence of synthetic biology approaches for cellular engineering is providing us with a broadly expanded set of tools for programming immune cells. We discuss how these tools could be used to design the next generation of smart T cell precision therapeutics." @default.
• W2587691649 created "2017-02-17" @default.
• W2587691649 creator A5006257775 @default.
• W2587691649 creator A5008558372 @default.
• W2587691649 date "2017-02-01" @default.
• W2587691649 modified "2023-10-11" @default.
• W2587691649 title "The Principles of Engineering Immune Cells to Treat Cancer" @default.
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