Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587697776> ?p ?o ?g. }
- W2587697776 endingPage "602" @default.
- W2587697776 startingPage "596" @default.
- W2587697776 abstract "Background: Arginine is considered to be an essential amino acid in various (patho)physiologic conditions of high demand. However, dietary arginine supplementation suffers from various drawbacks, including extensive first-pass extraction. Citrulline supplementation may be a better alternative than arginine, because its only fate in vivo is conversion into arginine.Objective: The goal of the present research was to determine the relative efficiency of arginine and citrulline supplementation to improve arginine availability.Methods: Six-week-old C57BL/6J male mice fitted with gastric catheters were adapted to 1 of 7 experimental diets for 2 wk. The basal diet contained 2.5 g l-arginine/kg, whereas the supplemented diets contained an additional 2.5, 7.5, and 12.5 g/kg diet of either l-arginine or l-citrulline. On the final day, after a 3-h food deprivation, mice were continuously infused intragastrically with an elemental diet similar to the dietary treatment, along with l-[13C6]arginine, to determine the splanchnic first-pass metabolism (FPM) of arginine. In addition, tracers were continuously infused intravenously to determine the fluxes and interconversions between citrulline and arginine. Linear regression slopes were compared to determine the relative efficiency of each supplement.Results: Whereas all the supplemented citrulline (105% ± 7% SEM) appeared in plasma and resulted in a marginal increase of 86% in arginine flux, supplemental arginine underwent an ∼70% FPM, indicating that only 30% of the supplemental arginine entered the peripheral circulation. However, supplemental arginine did not increase arginine flux. Both supplements linearly increased (P < 0.01) plasma arginine concentration from 109 μmol/L for the basal diet to 159 and 214 μmol/L for the highest arginine and citrulline supplementation levels, respectively. However, supplemental citrulline increased arginine concentrations to a greater extent (35%, P < 0.01).Conclusions: Citrulline supplementation is more efficient at increasing arginine availability than is arginine supplementation itself in mice." @default.
- W2587697776 created "2017-02-17" @default.
- W2587697776 creator A5000830148 @default.
- W2587697776 creator A5011916025 @default.
- W2587697776 creator A5022533714 @default.
- W2587697776 creator A5029363724 @default.
- W2587697776 creator A5063492627 @default.
- W2587697776 date "2017-04-01" @default.
- W2587697776 modified "2023-10-16" @default.
- W2587697776 title "Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice" @default.
- W2587697776 cites W147112024 @default.
- W2587697776 cites W1519365472 @default.
- W2587697776 cites W1607148144 @default.
- W2587697776 cites W1752346604 @default.
- W2587697776 cites W1881669090 @default.
- W2587697776 cites W1969714386 @default.
- W2587697776 cites W1972157068 @default.
- W2587697776 cites W1972526012 @default.
- W2587697776 cites W1973675750 @default.
- W2587697776 cites W1993721775 @default.
- W2587697776 cites W1998397225 @default.
- W2587697776 cites W1999853237 @default.
- W2587697776 cites W2007344373 @default.
- W2587697776 cites W2008954370 @default.
- W2587697776 cites W2025955704 @default.
- W2587697776 cites W2036256897 @default.
- W2587697776 cites W2038168279 @default.
- W2587697776 cites W2058006909 @default.
- W2587697776 cites W2062232972 @default.
- W2587697776 cites W2091819170 @default.
- W2587697776 cites W2091899373 @default.
- W2587697776 cites W2103004159 @default.
- W2587697776 cites W2111315684 @default.
- W2587697776 cites W2113863420 @default.
- W2587697776 cites W2115848027 @default.
- W2587697776 cites W2117442908 @default.
- W2587697776 cites W2125833733 @default.
- W2587697776 cites W2126817185 @default.
- W2587697776 cites W2134608721 @default.
- W2587697776 cites W2141345628 @default.
- W2587697776 cites W2145642904 @default.
- W2587697776 cites W2151684157 @default.
- W2587697776 cites W2162463567 @default.
- W2587697776 cites W2166020627 @default.
- W2587697776 cites W2168538439 @default.
- W2587697776 cites W2432195370 @default.
- W2587697776 cites W307678342 @default.
- W2587697776 doi "https://doi.org/10.3945/jn.116.240382" @default.
- W2587697776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5368575" @default.
- W2587697776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28179487" @default.
- W2587697776 hasPublicationYear "2017" @default.
- W2587697776 type Work @default.
- W2587697776 sameAs 2587697776 @default.
- W2587697776 citedByCount "50" @default.
- W2587697776 countsByYear W25876977762017 @default.
- W2587697776 countsByYear W25876977762018 @default.
- W2587697776 countsByYear W25876977762019 @default.
- W2587697776 countsByYear W25876977762020 @default.
- W2587697776 countsByYear W25876977762021 @default.
- W2587697776 countsByYear W25876977762022 @default.
- W2587697776 countsByYear W25876977762023 @default.
- W2587697776 crossrefType "journal-article" @default.
- W2587697776 hasAuthorship W2587697776A5000830148 @default.
- W2587697776 hasAuthorship W2587697776A5011916025 @default.
- W2587697776 hasAuthorship W2587697776A5022533714 @default.
- W2587697776 hasAuthorship W2587697776A5029363724 @default.
- W2587697776 hasAuthorship W2587697776A5063492627 @default.
- W2587697776 hasBestOaLocation W25876977761 @default.
- W2587697776 hasConcept C126322002 @default.
- W2587697776 hasConcept C134018914 @default.
- W2587697776 hasConcept C185592680 @default.
- W2587697776 hasConcept C2777468819 @default.
- W2587697776 hasConcept C2779129087 @default.
- W2587697776 hasConcept C515207424 @default.
- W2587697776 hasConcept C55493867 @default.
- W2587697776 hasConcept C71924100 @default.
- W2587697776 hasConcept C86803240 @default.
- W2587697776 hasConceptScore W2587697776C126322002 @default.
- W2587697776 hasConceptScore W2587697776C134018914 @default.
- W2587697776 hasConceptScore W2587697776C185592680 @default.
- W2587697776 hasConceptScore W2587697776C2777468819 @default.
- W2587697776 hasConceptScore W2587697776C2779129087 @default.
- W2587697776 hasConceptScore W2587697776C515207424 @default.
- W2587697776 hasConceptScore W2587697776C55493867 @default.
- W2587697776 hasConceptScore W2587697776C71924100 @default.
- W2587697776 hasConceptScore W2587697776C86803240 @default.
- W2587697776 hasIssue "4" @default.
- W2587697776 hasLocation W25876977761 @default.
- W2587697776 hasLocation W25876977762 @default.
- W2587697776 hasLocation W25876977763 @default.
- W2587697776 hasLocation W25876977764 @default.
- W2587697776 hasOpenAccess W2587697776 @default.
- W2587697776 hasPrimaryLocation W25876977761 @default.
- W2587697776 hasRelatedWork W1877864798 @default.
- W2587697776 hasRelatedWork W1971979964 @default.
- W2587697776 hasRelatedWork W2025955704 @default.
- W2587697776 hasRelatedWork W2044774921 @default.
- W2587697776 hasRelatedWork W2046728690 @default.