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- W2587711754 abstract "Significance Viruses rely completely on host cell metabolism to provide the building blocks and energy required for producing progeny virions. Infection by human cytomegalovirus (HCMV) induces significant alterations in glucose metabolism by increasing glucose uptake and glycolysis as well as redirecting glucose carbon to support the synthesis of biomolecules such as lipids. The significance of acetate as a nutrient has been ignored for a long period. Our studies show that glucose carbon can be converted to acetate and used to make cytosolic acetyl-CoA by acetyl-CoA synthetase short-chain family member 2 (ACSS2) for lipid synthesis, which is important for HCMV-induced lipogenesis and the viral growth. The study provides greater understanding of HCMV pathogenesis and suggests strategies to develop antiviral therapies." @default.
- W2587711754 created "2017-02-17" @default.
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- W2587711754 date "2017-02-06" @default.
- W2587711754 modified "2023-10-05" @default.
- W2587711754 title "ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection" @default.
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- W2587711754 doi "https://doi.org/10.1073/pnas.1614268114" @default.
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