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• W2587726300 abstract "Abstract Mammalian folliculogenesis is a complex process in which primordial follicles develop into pre-ovulatory follicles, followed by ovulation to release mature oocytes. In this study, we explored the role of miR-144 in ovulation. miR-144 was one of the differentially expressed microRNAs, which showed 5.59-fold changes, in pre-ovulatory ovarian follicles between Large White and Chinese Taihu sows detected by Solexa deep sequencing. We demonstrated that overexpression of miR-144 significantly decreased the luciferase reporter activity under the control of the cyclooxygenase-2 ( COX-2 ) or mothers against decapentaplegic homologue 4 ( Smad4 ) 3'-untranslated region (3'-UTR) and suppressed COX-2 and Smad4 expression. In contrast, a miR-144 inhibitor increased COX-2 and Smad4 expression in mouse granulosa cells (mGCs). Meanwhile, Smad4 upregulated COX-2 expression, but this effect was abolished when the mGCs were treated with the transforming growth factor beta signalling pathway inhibitor SB431542. Moreover, luciferase reporter, chromatin immunoprecipitation and electrophoretic mobility shift assay results showed that the transcription factor CP2 upregulated miR-144 expression, which partially contributed to the suppression of COX-2 in mGCs. Both CP2 and miR-144 alter prostaglandin E2 (PGE2) production by regulating COX-2 expression. In addition, miR-144 regulated mGC apoptosis and affected follicular atresia, but these activities did not appear to be through COX-2 and Smad4 . Taken together, we revealed an important CP2/miR-144/ COX-2 /PGE2/ovulation pathway in mGCs." @default.
• W2587726300 created "2017-02-17" @default.
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• W2587726300 date "2017-02-09" @default.
• W2587726300 modified "2023-10-10" @default.
• W2587726300 title "MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells" @default.
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• W2587726300 doi "https://doi.org/10.1038/cddis.2017.24" @default.
• W2587726300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5386473" @default.
• W2587726300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28182010" @default.
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