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• W2587788458 abstract "The aim of the present study was to investigate whether expression of monocyte and lymphocyte surface molecules differs between patients with severe sepsis and non‐septic patients treated in the intensive care unit ( ICU ). The expression of monocyte CD 14, CD 40, CD 80 and HLA ‐ DR , and lymphocyte CD 69 were analyzed using quantitative flow cytometry on three consecutive days in 27 patients with severe sepsis and in 15 non‐septic patients. Receiver operating characteristic analyses were performed and each corresponding area under the curve ( AUC ) was determined. The results showed that the expression levels of CD 40 on monocytes and CD 69 on CD 4+ T cells and on natural killer ( NK ) cells were highest in patients with severe sepsis (p < 0.05). Monocyte CD 40 and NK cell CD 69 expression levels were higher in patients with severe sepsis and positive blood culture compared with those with negative blood culture (p < 0.05). The highest values of AUC for severe sepsis detection were 0.836 for CD 40, 0.872 for CD 69 on NK cells, and 0.795 for CD 69 on CD 4+ T cells. These findings suggest that monocyte CD 40 and CD 69 on NK cells and CD 4+ T cells could prove useful for new approaches in the identification of severe sepsis in the ICU ." @default.
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• W2587788458 date "2017-02-17" @default.
• W2587788458 modified "2023-10-05" @default.
• W2587788458 title "Monocyte and lymphocyte surface molecules in severe sepsis and non-septic critically ill Patients" @default.
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• W2587788458 doi "https://doi.org/10.1111/apm.12670" @default.
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