Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587810512> ?p ?o ?g. }
- W2587810512 abstract "The pathogenesis of Inflammatory bowel diseases (IBD) is multifactorial, with interactions between genetic and environmental factors. Despite the existence of genetic factors being largely demonstrated by epidemiological data and several genetic studies, only a few findings have been useful in term of disease prediction, disease progression and targeting therapy. Areas covered: This review summarizes the results of genome-wide association studies in Crohn's disease, the role of epigenetics and the recent discovery by genetic studies of new pathogenetic pathways. Furthermore, it focuses on the importance of applying genetic data to clinical practice, and more specifically how to better target therapy and predict potential drug-related toxicity. Expert opinion: Some genetic markers identified in Crohn`s disease have allowed investigators to hypothesize about, and in some cases, prove the usefulness of new specific therapeutic agents. However, the heterogeneity and complexity of this disease has so far limited the daily clinical use of genetic information. Finally, the study of the implications of genetics on therapy, either to predict efficacy or avoid toxicity, is considered still to be in its infancy." @default.
- W2587810512 created "2017-02-24" @default.
- W2587810512 creator A5008170848 @default.
- W2587810512 creator A5036366637 @default.
- W2587810512 creator A5067846422 @default.
- W2587810512 creator A5073025318 @default.
- W2587810512 date "2017-03-01" @default.
- W2587810512 modified "2023-10-16" @default.
- W2587810512 title "Genetic risk variants as therapeutic targets for Crohn’s disease" @default.
- W2587810512 cites W1014257459 @default.
- W2587810512 cites W1549160607 @default.
- W2587810512 cites W1806755613 @default.
- W2587810512 cites W1826234378 @default.
- W2587810512 cites W1826915530 @default.
- W2587810512 cites W1862736662 @default.
- W2587810512 cites W1881640566 @default.
- W2587810512 cites W1967025862 @default.
- W2587810512 cites W1969767037 @default.
- W2587810512 cites W1976817865 @default.
- W2587810512 cites W1976935056 @default.
- W2587810512 cites W1981700839 @default.
- W2587810512 cites W1981714996 @default.
- W2587810512 cites W1982024411 @default.
- W2587810512 cites W1983251816 @default.
- W2587810512 cites W1983336154 @default.
- W2587810512 cites W1984666548 @default.
- W2587810512 cites W1985241425 @default.
- W2587810512 cites W1985707457 @default.
- W2587810512 cites W1986168633 @default.
- W2587810512 cites W1989021578 @default.
- W2587810512 cites W1991688187 @default.
- W2587810512 cites W1992711646 @default.
- W2587810512 cites W1998140184 @default.
- W2587810512 cites W2001478781 @default.
- W2587810512 cites W2005553679 @default.
- W2587810512 cites W2008755438 @default.
- W2587810512 cites W2011197968 @default.
- W2587810512 cites W2021283722 @default.
- W2587810512 cites W2023454175 @default.
- W2587810512 cites W2025840894 @default.
- W2587810512 cites W2040728839 @default.
- W2587810512 cites W2043015183 @default.
- W2587810512 cites W2047208232 @default.
- W2587810512 cites W2048931632 @default.
- W2587810512 cites W2054782645 @default.
- W2587810512 cites W2054966459 @default.
- W2587810512 cites W2055577456 @default.
- W2587810512 cites W2060643376 @default.
- W2587810512 cites W2060748779 @default.
- W2587810512 cites W2065603426 @default.
- W2587810512 cites W2073869570 @default.
- W2587810512 cites W2075090387 @default.
- W2587810512 cites W2077531651 @default.
- W2587810512 cites W2080969130 @default.
- W2587810512 cites W2081375829 @default.
- W2587810512 cites W2084802783 @default.
- W2587810512 cites W2085071828 @default.
- W2587810512 cites W2085127303 @default.
- W2587810512 cites W2088209062 @default.
- W2587810512 cites W2100443415 @default.
- W2587810512 cites W2101116570 @default.
- W2587810512 cites W2101777324 @default.
- W2587810512 cites W2101856875 @default.
- W2587810512 cites W2104747851 @default.
- W2587810512 cites W2106070528 @default.
- W2587810512 cites W2107805776 @default.
- W2587810512 cites W2112082141 @default.
- W2587810512 cites W2117414671 @default.
- W2587810512 cites W2117569516 @default.
- W2587810512 cites W2117974617 @default.
- W2587810512 cites W2122031852 @default.
- W2587810512 cites W2126660615 @default.
- W2587810512 cites W2126769079 @default.
- W2587810512 cites W2130049028 @default.
- W2587810512 cites W2134783591 @default.
- W2587810512 cites W2143625465 @default.
- W2587810512 cites W2143777796 @default.
- W2587810512 cites W2149585871 @default.
- W2587810512 cites W2149633671 @default.
- W2587810512 cites W2151871253 @default.
- W2587810512 cites W2154302514 @default.
- W2587810512 cites W2159448012 @default.
- W2587810512 cites W2161377277 @default.
- W2587810512 cites W2162217523 @default.
- W2587810512 cites W2164416409 @default.
- W2587810512 cites W2165290386 @default.
- W2587810512 cites W2167915961 @default.
- W2587810512 cites W2168647393 @default.
- W2587810512 cites W2169559894 @default.
- W2587810512 cites W2181009879 @default.
- W2587810512 cites W2234001938 @default.
- W2587810512 cites W2246276824 @default.
- W2587810512 cites W2254002107 @default.
- W2587810512 cites W2554913646 @default.
- W2587810512 cites W2555694062 @default.
- W2587810512 cites W2561041192 @default.
- W2587810512 cites W4231022815 @default.
- W2587810512 doi "https://doi.org/10.1080/14728222.2017.1296431" @default.
- W2587810512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28281904" @default.
- W2587810512 hasPublicationYear "2017" @default.