FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587817811> ?p ?o ?g. }

• W2587817811 abstract "Abstract Abstract 4515 Introduction: Acute kidney injury (AKI) is one of the most common complications after allogeneic stem cell transplantation (SCT). Although various post-transplant risk factors for AKI have been reported, there have been few studies which comprehensively assessed pre-transplant comorbidities and investigated their impact on the occurrence of AKI. Methods: We performed a retrospective analysis of 207 consecutive adult patients undergoing myeloablative or non-myeloablative SCT between 2001 and 2009. Cumulative incidence of AKI during the first 100 days was analyzed. AKI was defined and classified according to Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) criteria. Renal dysfunction considered to be associated with multiple organ dysfunction syndromes before death was excluded. The time to the development of severe AKI (defined as RIFLE class I or class F) was calculated and the multivariate analysis of pre- and post-transplant variables was performed by a Cox proportional hazards model. Post-transplant factors were assessed as time-dependent variables. As a representative of pre-transplant comorbidities, we used the hematopoietic cell transplantation-specific comorbidity index (HCT-CI). To analyze the outcomes of patients who developed AKI, the multivariate analysis of OS and NRM was carried out by a landmark approach, in which the follow-up was started at the onset of AKI class R or severe AKI in patients who developed AKI class R or severe AKI, and at the median time of the incidence of AKI in patients who did not develop AKI. Results: Among 207 patients, myeloablative SCT was performed in 149 patients and non-myeloablative SCT in 58 patients. Overall, 158 patients (76.3%) developed AKI, and 92 patients (44.4%) developed severe AKI. The median interval to the occurrence of severe AKI was 30 days after SCT. The cumulative incidence of severe AKI within 100 days in patients with a HCT-CI score 0, 1–2, and ≥3 was 21.3 %, 48.8%, and 73.9%, respectively. In a multivariate analysis, the HCT-CI was independently and most strongly associated with severe AKI (HCT-CI 1–2: adjusted hazard ratio [HR] 2.42, P<0.01; HCT-CI ≥3: adjusted HR 4.69, P<0.01), although no patients had renal dysfunction defined by the HCT-CI scoring system (pre-transplant creatinine > 2.0 mg/dl) before SCT in our cohort. Among post-transplant factors, sepsis (HR 2.66, P<0.01) and use of vancomycin (HR 1.79, P=0.04) were significantly associated with the development of severe AKI. In total, 101 of 207 patients (48.8%) died, of which 52 patients (51.5%) died of non-relapse causes. In a landmark analysis, the 3-year OS was 61.4% in patients without AKI, 53.9% in patients with AKI class R, and 39.3% in patients with severe AKI (P<0.01). The 3-year NRM was 5.6% in patients without AKI, 16.6% in patients with AKI class R, and 40.8% in patients with severe AKI (P<0.01). Multivariate analysis showed that severe AKI was a significant risk factor for worse OS (HR: 2.10, P=0.01) and NRM (HR: 6.15, P<0.01), while the occurrence of AKI class R did not have a strong impact on OS (HR: 1.14, P=0.69) or NRM (HR: 2.31, P=0.20). According to the cause of death, 24 patients died of severe AKI within 100 days after SCT, consisting of 2 on-disease patients (8.3% of the 24 patients who relapsed within 100 days after SCT) and 22 patients in remission (12.0% of the 183 patients who did not relapse within 100 days after SCT). There was no significant difference in the proportions of severe AKI as a mortality cause between patients with or without relapse (P=1.0). Conclusions: We found that high HCT-CI scores, particularly ≥3, were the most important pre-transplant predictor of severe AKI. The development of severe AKI within the first 100 days after SCT was independently associated with worse prognosis, irrespective of the status of the primary disease. Therefore, the strategy to prevent the occurrence of life-threatening severe AKI in patients with a high HCT-CI score would be imperative to improve their survival after allogeneic SCT. Disclosures: No relevant conflicts of interest to declare." @default.
• W2587817811 created "2017-02-24" @default.
• W2587817811 creator A5024179981 @default.
• W2587817811 creator A5066055908 @default.
• W2587817811 creator A5085709435 @default.
• W2587817811 creator A5090849761 @default.
• W2587817811 date "2010-11-19" @default.
• W2587817811 modified "2023-10-01" @default.
• W2587817811 title "Pre-Transplant Predictors and Post-Transplant Sequels of Acute Kidney Injury After Allogeneic Stem Cell Transplantation." @default.
• W2587817811 cites W1973215041 @default.
• W2587817811 cites W1973692643 @default.
• W2587817811 cites W1985527383 @default.
• W2587817811 cites W2002594255 @default.
• W2587817811 cites W2003992335 @default.
• W2587817811 cites W2007577432 @default.
• W2587817811 cites W2008912014 @default.
• W2587817811 cites W2009045383 @default.
• W2587817811 cites W2024037360 @default.
• W2587817811 cites W2031924566 @default.
• W2587817811 cites W2034344064 @default.
• W2587817811 cites W2043106562 @default.
• W2587817811 cites W2061924904 @default.
• W2587817811 cites W2089636012 @default.
• W2587817811 cites W2103830142 @default.
• W2587817811 cites W2117550229 @default.
• W2587817811 cites W2128281377 @default.
• W2587817811 cites W2128812336 @default.
• W2587817811 cites W2133348391 @default.
• W2587817811 cites W2139937737 @default.
• W2587817811 cites W2158104968 @default.
• W2587817811 cites W2318707941 @default.
• W2587817811 doi "https://doi.org/10.1182/blood.v116.21.4515.4515" @default.
• W2587817811 hasPublicationYear "2010" @default.
• W2587817811 type Work @default.
• W2587817811 sameAs 2587817811 @default.
• W2587817811 citedByCount "0" @default.
• W2587817811 crossrefType "journal-article" @default.
• W2587817811 hasAuthorship W2587817811A5024179981 @default.
• W2587817811 hasAuthorship W2587817811A5066055908 @default.
• W2587817811 hasAuthorship W2587817811A5085709435 @default.
• W2587817811 hasAuthorship W2587817811A5090849761 @default.
• W2587817811 hasConcept C120665830 @default.
• W2587817811 hasConcept C121332964 @default.
• W2587817811 hasConcept C126322002 @default.
• W2587817811 hasConcept C141071460 @default.
• W2587817811 hasConcept C166957645 @default.
• W2587817811 hasConcept C2777051993 @default.
• W2587817811 hasConcept C2777408962 @default.
• W2587817811 hasConcept C2779159551 @default.
• W2587817811 hasConcept C2780472472 @default.
• W2587817811 hasConcept C2911091166 @default.
• W2587817811 hasConcept C38180746 @default.
• W2587817811 hasConcept C50382708 @default.
• W2587817811 hasConcept C61511704 @default.
• W2587817811 hasConcept C71924100 @default.
• W2587817811 hasConcept C88879693 @default.
• W2587817811 hasConcept C95457728 @default.
• W2587817811 hasConceptScore W2587817811C120665830 @default.
• W2587817811 hasConceptScore W2587817811C121332964 @default.
• W2587817811 hasConceptScore W2587817811C126322002 @default.
• W2587817811 hasConceptScore W2587817811C141071460 @default.
• W2587817811 hasConceptScore W2587817811C166957645 @default.
• W2587817811 hasConceptScore W2587817811C2777051993 @default.
• W2587817811 hasConceptScore W2587817811C2777408962 @default.
• W2587817811 hasConceptScore W2587817811C2779159551 @default.
• W2587817811 hasConceptScore W2587817811C2780472472 @default.
• W2587817811 hasConceptScore W2587817811C2911091166 @default.
• W2587817811 hasConceptScore W2587817811C38180746 @default.
• W2587817811 hasConceptScore W2587817811C50382708 @default.
• W2587817811 hasConceptScore W2587817811C61511704 @default.
• W2587817811 hasConceptScore W2587817811C71924100 @default.
• W2587817811 hasConceptScore W2587817811C88879693 @default.
• W2587817811 hasConceptScore W2587817811C95457728 @default.
• W2587817811 hasLocation W25878178111 @default.
• W2587817811 hasOpenAccess W2587817811 @default.
• W2587817811 hasPrimaryLocation W25878178111 @default.
• W2587817811 hasRelatedWork W2044061273 @default.
• W2587817811 hasRelatedWork W2044320088 @default.
• W2587817811 hasRelatedWork W2166942667 @default.
• W2587817811 hasRelatedWork W2341698510 @default.
• W2587817811 hasRelatedWork W2354239630 @default.
• W2587817811 hasRelatedWork W2361188710 @default.
• W2587817811 hasRelatedWork W2394983965 @default.
• W2587817811 hasRelatedWork W2895548283 @default.
• W2587817811 hasRelatedWork W2899020432 @default.
• W2587817811 hasRelatedWork W2953481787 @default.
• W2587817811 hasRelatedWork W2972620341 @default.
• W2587817811 hasRelatedWork W3002168615 @default.
• W2587817811 hasRelatedWork W3007599986 @default.
• W2587817811 hasRelatedWork W3029157960 @default.
• W2587817811 hasRelatedWork W3031148250 @default.
• W2587817811 hasRelatedWork W3081132629 @default.
• W2587817811 hasRelatedWork W3089194351 @default.
• W2587817811 hasRelatedWork W3094956814 @default.
• W2587817811 hasRelatedWork W3116039671 @default.
• W2587817811 hasRelatedWork W3164537116 @default.
• W2587817811 isParatext "false" @default.
• W2587817811 isRetracted "false" @default.
• W2587817811 magId "2587817811" @default.
• W2587817811 workType "article" @default.