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- W2587849612 abstract "Background: There is a strong body of evidence regarding the relation between dietary behaviours, Body Mass Index (BMI), breast cancer (BC) incidence and risk of relapse. Recent data also suggest that overweight/obesity cause the activation of multiple inflammatory signaling pathways leading to the development and progression of BC. The purpose of our analysis was to understand if BMI can influence locally advanced breast cancer's development and clinical-pathological features and its relation with prognosis and response to neoadjuvant chemotherapy. Patients and methods: Data of consecutive patients undergoing NAC for LABC (stage II-III) between January 2007 and September 2015 from our Institution were retrospectively collected. According to BMI at diagnosis, three groups were identified: (a) ≤ 24.9(normal/underweight), (b)25.0 to 29.9(overweight), and (c) ≥ 30(obese). Blood-derived inflammatory indexes were collected. Chi-square test was used to test for interaction between patients' BMI and clinical-pathological features and to determine its value as prognostic and predictive factor. Relapse free survival (RFS) and overall survival (OS) were estimated using Kaplan-Meier method. Results: 124 patients with LABC were identified: 47% of them were overweight/obese, with a significant percentage of them was over 50 years old. No statistically significant relations were noted between groups b/c and pathological characteristics (bilateral/multifocal tumor, initial ER/PgR and HER2 status and its variation after chemotherapy, Ki-67%, lympho-vascular invasion) neither with pCR rate after NAC (p = 0.6), relapse-free survival and overall survival. Interestingly, overweight and obesity increased the risk (Odd ratio of 2,6) and were associated to the development of advanced stages of BC (53,2% vs 46,8%, p = 0.02). Groups b/c were significantly associated with higher levels of platelet/lymphocyte ratio (p= 0.04). Conclusion: Lower adherence or more challenges in Mammography Screening could explain an almost three-times increased risk of developing locally advanced BC, which is one of the main factors affecting breast cancer patients' prognosis. Obesity represents it-self a condition related to systemic inflammation and cancer. Much efforts in educational programs and closer monitoring programs should be taken in this subgroup patients, especially after 50 years." @default.
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- W2587849612 date "2016-09-01" @default.
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- W2587849612 title "The link between obesity and advanced breast cancer is a matter of much interest" @default.
- W2587849612 doi "https://doi.org/10.1093/annonc/mdw337.42" @default.
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