Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587877660> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2587877660 abstract "Preimplantation genetic screening has been proposed to improve the in-vitro fertilisation outcome by screening for aneuploid embryos or blastocysts. This study aimed to report the outcome of 133 cycles of preimplantation genetic diagnosis and screening by array comparative genomic hybridisation.This study of case series was conducted in a tertiary assisted reproductive centre in Hong Kong. Patients who underwent preimplantation genetic diagnosis for chromosomal abnormalities or preimplantation genetic screening between 1 April 2012 and 30 June 2015 were included. They underwent in-vitro fertilisation and intracytoplasmic sperm injection. An embryo biopsy was performed on day-3 embryos and the blastomere was subject to array comparative genomic hybridisation. Embryos with normal copy numbers were replaced. The ongoing pregnancy rate, implantation rate, and miscarriage rate were studied.During the study period, 133 cycles of preimplantation genetic diagnosis for chromosomal abnormalities or preimplantation genetic screening were initiated in 94 patients. Overall, 112 cycles proceeded to embryo biopsy and 65 cycles had embryo transfer. The ongoing pregnancy rate per transfer cycle after preimplantation genetic screening was 50.0% and that after preimplantation genetic diagnosis was 34.9%. The implantation rates after preimplantation genetic screening and diagnosis were 45.7% and 41.1%, respectively and the miscarriage rates were 8.3% and 28.6%, respectively. There were 26 frozen-thawed embryo transfer cycles, in which vitrified and biopsied genetically transferrable embryos were replaced, resulting in an ongoing pregnancy rate of 36.4% in the screening group and 60.0% in the diagnosis group.The clinical outcomes of preimplantation genetic diagnosis and screening using comparative genomic hybridisation in our unit were comparable to those reported internationally. Genetically transferrable embryos replaced in a natural cycle may improve the ongoing pregnancy rate and implantation rate when compared with transfer in a stimulated cycle." @default.
- W2587877660 created "2017-02-24" @default.
- W2587877660 creator A5002435410 @default.
- W2587877660 creator A5004229878 @default.
- W2587877660 creator A5043358415 @default.
- W2587877660 creator A5043668453 @default.
- W2587877660 creator A5067880078 @default.
- W2587877660 creator A5077898174 @default.
- W2587877660 date "2017-02-17" @default.
- W2587877660 modified "2023-10-01" @default.
- W2587877660 title "Preimplantation genetic diagnosis and screening by array comparative genomic hybridisation: experience of more than 100 cases in a single centre" @default.
- W2587877660 doi "https://doi.org/10.12809/hkmj164883" @default.
- W2587877660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28211357" @default.
- W2587877660 hasPublicationYear "2017" @default.
- W2587877660 type Work @default.
- W2587877660 sameAs 2587877660 @default.
- W2587877660 citedByCount "0" @default.
- W2587877660 crossrefType "journal-article" @default.
- W2587877660 hasAuthorship W2587877660A5002435410 @default.
- W2587877660 hasAuthorship W2587877660A5004229878 @default.
- W2587877660 hasAuthorship W2587877660A5043358415 @default.
- W2587877660 hasAuthorship W2587877660A5043668453 @default.
- W2587877660 hasAuthorship W2587877660A5067880078 @default.
- W2587877660 hasAuthorship W2587877660A5077898174 @default.
- W2587877660 hasBestOaLocation W25878776601 @default.
- W2587877660 hasConcept C126322002 @default.
- W2587877660 hasConcept C131872663 @default.
- W2587877660 hasConcept C160099875 @default.
- W2587877660 hasConcept C16685009 @default.
- W2587877660 hasConcept C196843134 @default.
- W2587877660 hasConcept C2776537878 @default.
- W2587877660 hasConcept C2778278907 @default.
- W2587877660 hasConcept C2778279030 @default.
- W2587877660 hasConcept C2778642596 @default.
- W2587877660 hasConcept C2778805741 @default.
- W2587877660 hasConcept C2779234561 @default.
- W2587877660 hasConcept C2779245376 @default.
- W2587877660 hasConcept C2780343435 @default.
- W2587877660 hasConcept C2780673598 @default.
- W2587877660 hasConcept C29456083 @default.
- W2587877660 hasConcept C512716672 @default.
- W2587877660 hasConcept C54355233 @default.
- W2587877660 hasConcept C68760520 @default.
- W2587877660 hasConcept C71924100 @default.
- W2587877660 hasConcept C86803240 @default.
- W2587877660 hasConcept C87073359 @default.
- W2587877660 hasConceptScore W2587877660C126322002 @default.
- W2587877660 hasConceptScore W2587877660C131872663 @default.
- W2587877660 hasConceptScore W2587877660C160099875 @default.
- W2587877660 hasConceptScore W2587877660C16685009 @default.
- W2587877660 hasConceptScore W2587877660C196843134 @default.
- W2587877660 hasConceptScore W2587877660C2776537878 @default.
- W2587877660 hasConceptScore W2587877660C2778278907 @default.
- W2587877660 hasConceptScore W2587877660C2778279030 @default.
- W2587877660 hasConceptScore W2587877660C2778642596 @default.
- W2587877660 hasConceptScore W2587877660C2778805741 @default.
- W2587877660 hasConceptScore W2587877660C2779234561 @default.
- W2587877660 hasConceptScore W2587877660C2779245376 @default.
- W2587877660 hasConceptScore W2587877660C2780343435 @default.
- W2587877660 hasConceptScore W2587877660C2780673598 @default.
- W2587877660 hasConceptScore W2587877660C29456083 @default.
- W2587877660 hasConceptScore W2587877660C512716672 @default.
- W2587877660 hasConceptScore W2587877660C54355233 @default.
- W2587877660 hasConceptScore W2587877660C68760520 @default.
- W2587877660 hasConceptScore W2587877660C71924100 @default.
- W2587877660 hasConceptScore W2587877660C86803240 @default.
- W2587877660 hasConceptScore W2587877660C87073359 @default.
- W2587877660 hasLocation W25878776601 @default.
- W2587877660 hasLocation W25878776602 @default.
- W2587877660 hasOpenAccess W2587877660 @default.
- W2587877660 hasPrimaryLocation W25878776601 @default.
- W2587877660 hasRelatedWork W2157903360 @default.
- W2587877660 hasRelatedWork W2587877660 @default.
- W2587877660 hasRelatedWork W2609111305 @default.
- W2587877660 hasRelatedWork W2803307889 @default.
- W2587877660 hasRelatedWork W2946676203 @default.
- W2587877660 hasRelatedWork W3080455754 @default.
- W2587877660 hasRelatedWork W3091940204 @default.
- W2587877660 hasRelatedWork W3134822525 @default.
- W2587877660 hasRelatedWork W3139101991 @default.
- W2587877660 hasRelatedWork W4289954989 @default.
- W2587877660 isParatext "false" @default.
- W2587877660 isRetracted "false" @default.
- W2587877660 magId "2587877660" @default.
- W2587877660 workType "article" @default.