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• W2587922577 abstract "// Rupeng Zhang 1, 4, 5 , Yuenan Guo 1, 4, 5 , Zhenchi Ma 1, 4, 5 , Gang Ma 2, 4, 5 , Qiang Xue 1, 4, 5 , Fangxuan Li 3, 4, 5 , Liren Liu 2, 4, 5 1 Department of Gastric Cancer Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 2 Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 3 Department of Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 4 National Clinical Research Center of Cancer, Tianjin 300060, China 5 Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China Correspondence to: Rupeng Zhang, email: tijzhangrp@163.com Liren Liu, email: liuliren@tjmuch.com Keywords: PTENP1, miR-106b, miR-93, long non-coding RNA, gastric cancer Received: October 20, 2016      Accepted: January 29, 2017      Published: February 13, 2017 ABSTRACT Recent studies have shown that competing endogenous RNAs (ceRNAs) play an important role in the regulation of gene expression, and participate in a wide range of biological processes, including carcinogenesis. Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies. However, whether a PTENP1~miRNA~PTEN ceRNA network exists and how it functions in gastric cancer (GC) remains elusive. In order to identify and characterize the PTENP1~miRNA~PTEN ceRNA network in GC, we first determined PTENP1 levels in clinical GC samples and found that PTENP1 and PTEN were concurrently downregulated in these samples. We further demonstrated that PTENP1 could act as a ceRNA to sponge miR-106b and miR-93 from targeting PTEN for downregulation using a novel ceRNA in vitro gradient assay. Thus, we revealed a tumor suppressive role of PTENP1 as ceRNA in GC and pinpointed the specific miRNAs decoyed by PTENP1, highlighting the emerging roles of ceRNAs in the biological regulation of GC cells and their possible clinical significance." @default.
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• W2587922577 date "2017-02-13" @default.
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• W2587922577 title "Long non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer" @default.
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• W2587922577 doi "https://doi.org/10.18632/oncotarget.15317" @default.
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