Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587931937> ?p ?o ?g. }
- W2587931937 endingPage "140" @default.
- W2587931937 startingPage "128" @default.
- W2587931937 abstract "This brief review aims to provide an updated account of the cardiovascular events of awakening, proposing a testable conceptual framework that links these events with the neural control of sleep and the autonomic nervous system, with focus on the hypothalamic orexin (hypocretin) neurons. Awakening from non-rapid-eye-movement sleep entails coordinated changes in brain and cardiovascular activity: the neural “flip–flop” switch that governs state transitions becomes biased toward the ascending arousal systems, arterial blood pressure and heart rate rise toward waking values, and distal skin temperature falls. Arterial blood pressure and skin temperature are sensed by baroreceptors and thermoreceptors and may positively feedback on the brain wake–sleep switch, thus contributing to sharpen, coordinate, and stabilize awakening. These effects may be enhanced by the hypothalamic orexin neurons, which may modulate the changes in blood pressure, heart rate, and skin temperature upon awakening, while biasing the wake–sleep switch toward wakefulness through direct neural projections. A deeper understanding of the cardiovascular events of awakening and of their links with skin temperature and the wake–sleep neural switch may lead to better treatments options for patients with narcolepsy type 1, who lack the orexin neurons." @default.
- W2587931937 created "2017-02-24" @default.
- W2587931937 creator A5011726416 @default.
- W2587931937 date "2017-02-16" @default.
- W2587931937 modified "2023-10-14" @default.
- W2587931937 title "Orexins and the cardiovascular events of awakening" @default.
- W2587931937 cites W1517186213 @default.
- W2587931937 cites W1519232679 @default.
- W2587931937 cites W1576130054 @default.
- W2587931937 cites W1604815012 @default.
- W2587931937 cites W1612453552 @default.
- W2587931937 cites W1627229807 @default.
- W2587931937 cites W1703677612 @default.
- W2587931937 cites W1829186012 @default.
- W2587931937 cites W1895384166 @default.
- W2587931937 cites W1943576895 @default.
- W2587931937 cites W1964507022 @default.
- W2587931937 cites W1970709955 @default.
- W2587931937 cites W1972269081 @default.
- W2587931937 cites W1972967055 @default.
- W2587931937 cites W197495535 @default.
- W2587931937 cites W1978920053 @default.
- W2587931937 cites W1979151764 @default.
- W2587931937 cites W1989776859 @default.
- W2587931937 cites W1990407554 @default.
- W2587931937 cites W1992138108 @default.
- W2587931937 cites W1993997953 @default.
- W2587931937 cites W1995612990 @default.
- W2587931937 cites W2002019025 @default.
- W2587931937 cites W2002415922 @default.
- W2587931937 cites W2003528905 @default.
- W2587931937 cites W2003777173 @default.
- W2587931937 cites W2010899716 @default.
- W2587931937 cites W2011580879 @default.
- W2587931937 cites W2024609999 @default.
- W2587931937 cites W2028121897 @default.
- W2587931937 cites W2029048820 @default.
- W2587931937 cites W2029479262 @default.
- W2587931937 cites W2031462960 @default.
- W2587931937 cites W2032530293 @default.
- W2587931937 cites W2038008568 @default.
- W2587931937 cites W2039556272 @default.
- W2587931937 cites W2041165658 @default.
- W2587931937 cites W2041554833 @default.
- W2587931937 cites W2044393257 @default.
- W2587931937 cites W2044991970 @default.
- W2587931937 cites W2050227464 @default.
- W2587931937 cites W2050740583 @default.
- W2587931937 cites W2061886084 @default.
- W2587931937 cites W2064149389 @default.
- W2587931937 cites W2064442671 @default.
- W2587931937 cites W2065349496 @default.
- W2587931937 cites W2065354622 @default.
- W2587931937 cites W2068040224 @default.
- W2587931937 cites W2068263478 @default.
- W2587931937 cites W2072154498 @default.
- W2587931937 cites W2072567022 @default.
- W2587931937 cites W2074089568 @default.
- W2587931937 cites W2076360063 @default.
- W2587931937 cites W2079405327 @default.
- W2587931937 cites W2079825374 @default.
- W2587931937 cites W2082662916 @default.
- W2587931937 cites W2086714775 @default.
- W2587931937 cites W2087909465 @default.
- W2587931937 cites W2089676642 @default.
- W2587931937 cites W2090111937 @default.
- W2587931937 cites W2090740605 @default.
- W2587931937 cites W2093315419 @default.
- W2587931937 cites W2101578047 @default.
- W2587931937 cites W2110175860 @default.
- W2587931937 cites W2113657825 @default.
- W2587931937 cites W2113836851 @default.
- W2587931937 cites W2120050604 @default.
- W2587931937 cites W2120543763 @default.
- W2587931937 cites W2125708963 @default.
- W2587931937 cites W2134923404 @default.
- W2587931937 cites W2135538835 @default.
- W2587931937 cites W2136288313 @default.
- W2587931937 cites W2139578548 @default.
- W2587931937 cites W2145219354 @default.
- W2587931937 cites W2147461278 @default.
- W2587931937 cites W2150515709 @default.
- W2587931937 cites W2150795997 @default.
- W2587931937 cites W2151050452 @default.
- W2587931937 cites W2152527426 @default.
- W2587931937 cites W2154984953 @default.
- W2587931937 cites W2155964720 @default.
- W2587931937 cites W2156294491 @default.
- W2587931937 cites W2159953069 @default.
- W2587931937 cites W2162007196 @default.
- W2587931937 cites W2164803343 @default.
- W2587931937 cites W2165996850 @default.
- W2587931937 cites W2168415226 @default.
- W2587931937 cites W2168638573 @default.
- W2587931937 cites W2182259011 @default.
- W2587931937 cites W2200412458 @default.
- W2587931937 cites W2209502002 @default.
- W2587931937 cites W2225258777 @default.