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• W2587947260 abstract "A novel five-component strategy involving commercially available diketene, primary amines, malononitrile and various benzaldehydes for the synthesis of densely functionalized 1,4-dihydropyridines in good yields was achieved. The reaction pathway involves a sequential ring-opening of diketene/enamine formation/Knoevenagel-condensation/Michael addition and 6-exo-tet cyclization, resulting in multiple bond-formation events including two C–C and three C–N bonds ultimately leading to the formation of the respective 1,4-dihydropyridines." @default.
• W2587947260 created "2017-02-24" @default.
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• W2587947260 date "2017-04-01" @default.
• W2587947260 modified "2023-10-13" @default.
• W2587947260 title "Five-component synthesis of dihydropyridines based on diketene" @default.
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• W2587947260 doi "https://doi.org/10.1016/j.tet.2017.02.027" @default.
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