FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587978341> ?p ?o ?g. }

• W2587978341 endingPage "e1296610" @default.
• W2587978341 startingPage "e1296610" @default.
• W2587978341 abstract "Neutrophil extracellular trap (NET) formation represents a unique effector function of neutrophils (PMN). The mechanism of NET release in response to bacteria is largely unknown. We studied the process by which Pseudomonas aeruginosa, an opportunistic pathogen, interacts with primary PMNs, and found that flagellar swimming motility of the bacterium is essential for inducing NET extrusion. Cystic fibrosis (CF) lung disease is associated with P. aeruginosa infection and PMN-dominated inflammation. Although NETs are abundant in CF airways, the main factors triggering NET release in CF remain unclear. Our study implicates that motile P. aeruginosa is a strong NET-inducer in CF. In early stages of CF lung disease flagellated, motile isolates of P. aeruginosa are characteristic and their interactions with PMNs could lead to NET formation. In chronic CF, P. aeruginosa down-regulates its flagellum expression to avoid recognition by the immune system and forms biofilms. Flagellated bacteria, however, are released from biofilms and could interact with PMNs to form NETs. Although flagellated forms likely represent only a small fraction of the total P. aeruginosa load in chronic CF, NET release induced by them could have a significant impact on inflammation and lung function since flagellated forms trigger the most robust response of the immune system including PMNs.Overall, we speculate that NET formation driven by motile P. aeruginosa could be a novel, significant contributor to pathogenesis at both, early and late stages of CF lung disease." @default.
• W2587978341 created "2017-02-24" @default.
• W2587978341 creator A5083126492 @default.
• W2587978341 date "2017-02-17" @default.
• W2587978341 modified "2023-09-25" @default.
• W2587978341 title "Neutrophil extracellular trap release driven by bacterial motility: Relevance to cystic fibrosis lung disease" @default.
• W2587978341 cites W1491668332 @default.
• W2587978341 cites W1564903449 @default.
• W2587978341 cites W1798627903 @default.
• W2587978341 cites W1939560362 @default.
• W2587978341 cites W1940030194 @default.
• W2587978341 cites W1985157432 @default.
• W2587978341 cites W1997259399 @default.
• W2587978341 cites W2001336488 @default.
• W2587978341 cites W2006289124 @default.
• W2587978341 cites W2032456876 @default.
• W2587978341 cites W2042498906 @default.
• W2587978341 cites W2052318993 @default.
• W2587978341 cites W2054704409 @default.
• W2587978341 cites W2055244576 @default.
• W2587978341 cites W2055261049 @default.
• W2587978341 cites W2068148539 @default.
• W2587978341 cites W2080335548 @default.
• W2587978341 cites W2096684565 @default.
• W2587978341 cites W2097560724 @default.
• W2587978341 cites W2102072203 @default.
• W2587978341 cites W2124574237 @default.
• W2587978341 cites W2128057907 @default.
• W2587978341 cites W2130663948 @default.
• W2587978341 cites W2144292013 @default.
• W2587978341 cites W2148054572 @default.
• W2587978341 cites W2149908911 @default.
• W2587978341 cites W2156361445 @default.
• W2587978341 cites W2163770914 @default.
• W2587978341 cites W2192402885 @default.
• W2587978341 cites W2301131921 @default.
• W2587978341 cites W2552492585 @default.
• W2587978341 doi "https://doi.org/10.1080/19420889.2017.1296610" @default.
• W2587978341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5398203" @default.
• W2587978341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28451056" @default.
• W2587978341 hasPublicationYear "2017" @default.
• W2587978341 type Work @default.
• W2587978341 sameAs 2587978341 @default.
• W2587978341 citedByCount "17" @default.
• W2587978341 countsByYear W25879783412017 @default.
• W2587978341 countsByYear W25879783412018 @default.
• W2587978341 countsByYear W25879783412019 @default.
• W2587978341 countsByYear W25879783412020 @default.
• W2587978341 countsByYear W25879783412021 @default.
• W2587978341 countsByYear W25879783412022 @default.
• W2587978341 countsByYear W25879783412023 @default.
• W2587978341 crossrefType "journal-article" @default.
• W2587978341 hasAuthorship W2587978341A5083126492 @default.
• W2587978341 hasBestOaLocation W25879783411 @default.
• W2587978341 hasConcept C115811362 @default.
• W2587978341 hasConcept C126322002 @default.
• W2587978341 hasConcept C134897094 @default.
• W2587978341 hasConcept C170493617 @default.
• W2587978341 hasConcept C203014093 @default.
• W2587978341 hasConcept C2776460866 @default.
• W2587978341 hasConcept C2776914184 @default.
• W2587978341 hasConcept C2776938444 @default.
• W2587978341 hasConcept C2777637488 @default.
• W2587978341 hasConcept C2777714996 @default.
• W2587978341 hasConcept C2780942790 @default.
• W2587978341 hasConcept C28406088 @default.
• W2587978341 hasConcept C523546767 @default.
• W2587978341 hasConcept C54166955 @default.
• W2587978341 hasConcept C54355233 @default.
• W2587978341 hasConcept C58123911 @default.
• W2587978341 hasConcept C58207958 @default.
• W2587978341 hasConcept C71924100 @default.
• W2587978341 hasConcept C86803240 @default.
• W2587978341 hasConcept C8891405 @default.
• W2587978341 hasConcept C89423630 @default.
• W2587978341 hasConcept C95444343 @default.
• W2587978341 hasConceptScore W2587978341C115811362 @default.
• W2587978341 hasConceptScore W2587978341C126322002 @default.
• W2587978341 hasConceptScore W2587978341C134897094 @default.
• W2587978341 hasConceptScore W2587978341C170493617 @default.
• W2587978341 hasConceptScore W2587978341C203014093 @default.
• W2587978341 hasConceptScore W2587978341C2776460866 @default.
• W2587978341 hasConceptScore W2587978341C2776914184 @default.
• W2587978341 hasConceptScore W2587978341C2776938444 @default.
• W2587978341 hasConceptScore W2587978341C2777637488 @default.
• W2587978341 hasConceptScore W2587978341C2777714996 @default.
• W2587978341 hasConceptScore W2587978341C2780942790 @default.
• W2587978341 hasConceptScore W2587978341C28406088 @default.
• W2587978341 hasConceptScore W2587978341C523546767 @default.
• W2587978341 hasConceptScore W2587978341C54166955 @default.
• W2587978341 hasConceptScore W2587978341C54355233 @default.
• W2587978341 hasConceptScore W2587978341C58123911 @default.
• W2587978341 hasConceptScore W2587978341C58207958 @default.
• W2587978341 hasConceptScore W2587978341C71924100 @default.
• W2587978341 hasConceptScore W2587978341C86803240 @default.
• W2587978341 hasConceptScore W2587978341C8891405 @default.
• W2587978341 hasConceptScore W2587978341C89423630 @default.
• W2587978341 hasConceptScore W2587978341C95444343 @default.

• next