FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2587980083> ?p ?o ?g. }

• W2587980083 endingPage "iv12" @default.
• W2587980083 startingPage "iv12" @default.
• W2587980083 abstract "Background: There is an increasing evidence supporting tumor-infiltrating lymphocytes (TILs) as a prognostic and predictive factors in different human neoplasm (melanoma, colon rectal, triple negative breast cancer), actually a positive correlation was found between total TILs levels and better outcomes independently from the TNM classification. Material (patients) and methods: We retrospectively evaluated the correlation between TILS and prognosis in early stage of NSCLC operated at our Hospital from 2012 to 2013 and we made a comparison with classic clinical-pathological features (stage, T, N, histological type, adjuvant treatment, chronic corticosteroid treatment and smoking habits) by performing univariate analysis of survival. Determination of TILs has been performed on FFPE tissue samples and characterized with pathologic examinations of H&E-stained sections. Tumor-infiltrating lymphocytes (TILs) are usually measured using subjective methods. In the absence of a standardized methodology for evaluating TILs in NSCLC, we took as a reference the recommendations by International TILs Working Group 2014 for breast cancer (Salgado et Al.) Results: We collected data from 58 pts, median age 71 (range 42-85), 49 pts with stage I e 9 pts stage II, 58% pts with adenocarcinoma, 32,7% squamocellular carcinoma and 8% with neuroendocrine/large cell carcinoma. The OS and DFS at 48 months of follow up was respectively 77,6% and 74,1 %. The presence of low level of TILs (< 10%) was found in 57% pts and middle-high (>10%) in 43% of them. The increased level of TILs was significantly correlated with OS (p 0,044) but not with PFS (0,391) in our analysis. The totality of patient with squamocellular histological subtype and middle-high level of TILs was alive at 48 months, although p value wasn't statistically significant. No other significant correlations has been found with the other clinical-pathological features. Conclusions: In our population the quantitative measurement of TILs have been shown to provide a prognostic significance, although their inclusion in the diagnostic practice necessitates a wide recognized method together with the characterization of the lymphocytes subtypes that seems to have different predictive value." @default.
• W2587980083 created "2017-02-24" @default.
• W2587980083 creator A5001447975 @default.
• W2587980083 creator A5027324967 @default.
• W2587980083 creator A5054052615 @default.
• W2587980083 creator A5068497911 @default.
• W2587980083 creator A5069020227 @default.
• W2587980083 creator A5076532088 @default.
• W2587980083 creator A5077371873 @default.
• W2587980083 date "2016-09-01" @default.
• W2587980083 modified "2023-09-30" @default.
• W2587980083 title "TILs evaluation in early stages of NSCLC" @default.
• W2587980083 doi "https://doi.org/10.1093/annonc/mdw332.28" @default.
• W2587980083 hasPublicationYear "2016" @default.
• W2587980083 type Work @default.
• W2587980083 sameAs 2587980083 @default.
• W2587980083 citedByCount "0" @default.
• W2587980083 crossrefType "journal-article" @default.
• W2587980083 hasAuthorship W2587980083A5001447975 @default.
• W2587980083 hasAuthorship W2587980083A5027324967 @default.
• W2587980083 hasAuthorship W2587980083A5054052615 @default.
• W2587980083 hasAuthorship W2587980083A5068497911 @default.
• W2587980083 hasAuthorship W2587980083A5069020227 @default.
• W2587980083 hasAuthorship W2587980083A5076532088 @default.
• W2587980083 hasAuthorship W2587980083A5077371873 @default.
• W2587980083 hasBestOaLocation W25879800831 @default.
• W2587980083 hasConcept C121608353 @default.
• W2587980083 hasConcept C126322002 @default.
• W2587980083 hasConcept C143998085 @default.
• W2587980083 hasConcept C144301174 @default.
• W2587980083 hasConcept C146357865 @default.
• W2587980083 hasConcept C151730666 @default.
• W2587980083 hasConcept C2777701055 @default.
• W2587980083 hasConcept C2778326572 @default.
• W2587980083 hasConcept C2781182431 @default.
• W2587980083 hasConcept C38180746 @default.
• W2587980083 hasConcept C526805850 @default.
• W2587980083 hasConcept C530470458 @default.
• W2587980083 hasConcept C71924100 @default.
• W2587980083 hasConcept C86803240 @default.
• W2587980083 hasConceptScore W2587980083C121608353 @default.
• W2587980083 hasConceptScore W2587980083C126322002 @default.
• W2587980083 hasConceptScore W2587980083C143998085 @default.
• W2587980083 hasConceptScore W2587980083C144301174 @default.
• W2587980083 hasConceptScore W2587980083C146357865 @default.
• W2587980083 hasConceptScore W2587980083C151730666 @default.
• W2587980083 hasConceptScore W2587980083C2777701055 @default.
• W2587980083 hasConceptScore W2587980083C2778326572 @default.
• W2587980083 hasConceptScore W2587980083C2781182431 @default.
• W2587980083 hasConceptScore W2587980083C38180746 @default.
• W2587980083 hasConceptScore W2587980083C526805850 @default.
• W2587980083 hasConceptScore W2587980083C530470458 @default.
• W2587980083 hasConceptScore W2587980083C71924100 @default.
• W2587980083 hasConceptScore W2587980083C86803240 @default.
• W2587980083 hasLocation W25879800831 @default.
• W2587980083 hasOpenAccess W2587980083 @default.
• W2587980083 hasPrimaryLocation W25879800831 @default.
• W2587980083 hasRelatedWork W1999960801 @default.
• W2587980083 hasRelatedWork W2563193111 @default.
• W2587980083 hasRelatedWork W2801241205 @default.
• W2587980083 hasRelatedWork W2921993685 @default.
• W2587980083 hasRelatedWork W3135028047 @default.
• W2587980083 hasRelatedWork W3141065388 @default.
• W2587980083 hasRelatedWork W3207434196 @default.
• W2587980083 hasRelatedWork W377899687 @default.
• W2587980083 hasRelatedWork W4220726198 @default.
• W2587980083 hasRelatedWork W4285987888 @default.
• W2587980083 hasVolume "27" @default.
• W2587980083 isParatext "false" @default.
• W2587980083 isRetracted "false" @default.
• W2587980083 magId "2587980083" @default.
• W2587980083 workType "article" @default.