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• W2588045392 abstract "Background: Cutaneous leishmaniasis lacks effective and well-tolerated treatments. The current therapies mainly rely on&#x0D; antimonial drugs that are inadequate because of their poor efficacy. Traditional medicine offers a complementary&#x0D; alternative for the treatment of various diseases. Additionally, several plants have shown success as anti-leishmanial agents.&#x0D; Therefore, we sought to evaluate the in vitro and in vivo activity of MEBA against Leishmania mexicana.&#x0D; Materials and Methods: Methanolic extract of B. aptera was obtained by macetration, after we determined in vitro antileishmanial&#x0D; activity of MEBA by MTT assay and the induced apoptosis in promastigotes by flow cytometry. To analyze the&#x0D; in vivo anti-leishmanial activity, we used infected mice that were treated and not treated with MEBA and we determined the&#x0D; levels of cytokines using ELISA. The phytochemical properties were determined by CG-MS and DPPH assay.&#x0D; Results: We determined of LC50 of 0.408 mg/mL of MEBA for in vitro anti-leishmanial activity. MEBA induced apoptosis&#x0D; in promastigotes (15.3% ± 0.86). Treated mice exhibited smaller lesions and contained significantly fewer parasites than&#x0D; did untreated mice; in addition, we found that IFN-γ and TNF-α increased in the sera of MEBA-treated mice. GC-MS&#x0D; analysis showed that podophyllotoxin was the most abundant compound. Evaluation of the activity by DPPH assay&#x0D; demonstrated an SC50 of 11.72 μg/mL.&#x0D; Conclusion: Based on the above data, it was concluded that MEBA is a good candidate in the search for new antileishmanial&#x0D; agents." @default.
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• W2588045392 date "2017-01-13" @default.
• W2588045392 modified "2023-10-16" @default.
• W2588045392 title "IN VIVO AND IN VITRO ANTILEISHMANIAL EFFECTS OF METHANOLIC EXTRACT FROM BARK OF BURSERA APTERA" @default.
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• W2588045392 doi "https://doi.org/10.21010/ajtcam.v14i2.20" @default.
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