Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588048543> ?p ?o ?g. }
- W2588048543 endingPage "373" @default.
- W2588048543 startingPage "373" @default.
- W2588048543 abstract "Soy-leaf extracts exert their cardioprotective effects by inducing endothelium-dependent vasodilation in the arteries, and they favorably modulate the serum lipid profile. In this study, we investigated the atheroprotective effects of an ethanol extract of soy leaf (ESL) in human umbilical vein endothelial cells (HUVECs) and high-cholesterol diet (HCD)-fed low-density lipoprotein receptor deficient (LDLR−/−) mice. ESL induced the expression of Krüppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-α (TNF-α)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs. ESL supplementation reduced aortic lesion formation in Western diet-fed LDLR−/− mice by 46% (p < 0.01) compared to the HCD group. ESL also markedly decreased the aortic expression levels of VCAM-1, ICAM-1, monocyte chemotactic protein-1 (MCP-1), TNF-α, IL-6, IL-1β, matrix metallopeptidase 9 (MMP-9), and fractalkine, while the expression of KLF2 was significantly increased. These results suggest that ESL supplementation has potential for preventing HCD-induced atherosclerosis effectively." @default.
- W2588048543 created "2017-02-24" @default.
- W2588048543 creator A5011687488 @default.
- W2588048543 creator A5014307727 @default.
- W2588048543 creator A5017521861 @default.
- W2588048543 creator A5022862706 @default.
- W2588048543 creator A5054609444 @default.
- W2588048543 creator A5055388143 @default.
- W2588048543 creator A5085617964 @default.
- W2588048543 date "2017-02-10" @default.
- W2588048543 modified "2023-10-16" @default.
- W2588048543 title "Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Krüppel-Like Factor 2 and Adhesion Molecules" @default.
- W2588048543 cites W1888105809 @default.
- W2588048543 cites W1912737988 @default.
- W2588048543 cites W1964220568 @default.
- W2588048543 cites W2005517764 @default.
- W2588048543 cites W2014878937 @default.
- W2588048543 cites W2017871510 @default.
- W2588048543 cites W2019783107 @default.
- W2588048543 cites W2021051379 @default.
- W2588048543 cites W2023177867 @default.
- W2588048543 cites W2037328556 @default.
- W2588048543 cites W2040080690 @default.
- W2588048543 cites W2042408301 @default.
- W2588048543 cites W2042647327 @default.
- W2588048543 cites W2043819033 @default.
- W2588048543 cites W2050327228 @default.
- W2588048543 cites W2060705626 @default.
- W2588048543 cites W2068863073 @default.
- W2588048543 cites W2073864769 @default.
- W2588048543 cites W2079834695 @default.
- W2588048543 cites W2080274811 @default.
- W2588048543 cites W2094941678 @default.
- W2588048543 cites W2098459972 @default.
- W2588048543 cites W2099300133 @default.
- W2588048543 cites W2112098540 @default.
- W2588048543 cites W2113574245 @default.
- W2588048543 cites W2127649624 @default.
- W2588048543 cites W2133546870 @default.
- W2588048543 cites W2140915672 @default.
- W2588048543 cites W2142417834 @default.
- W2588048543 cites W2147919276 @default.
- W2588048543 cites W2171571237 @default.
- W2588048543 cites W2209510125 @default.
- W2588048543 doi "https://doi.org/10.3390/ijms18020373" @default.
- W2588048543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5343908" @default.
- W2588048543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28208647" @default.
- W2588048543 hasPublicationYear "2017" @default.
- W2588048543 type Work @default.
- W2588048543 sameAs 2588048543 @default.
- W2588048543 citedByCount "24" @default.
- W2588048543 countsByYear W25880485432017 @default.
- W2588048543 countsByYear W25880485432018 @default.
- W2588048543 countsByYear W25880485432019 @default.
- W2588048543 countsByYear W25880485432020 @default.
- W2588048543 countsByYear W25880485432021 @default.
- W2588048543 countsByYear W25880485432022 @default.
- W2588048543 countsByYear W25880485432023 @default.
- W2588048543 crossrefType "journal-article" @default.
- W2588048543 hasAuthorship W2588048543A5011687488 @default.
- W2588048543 hasAuthorship W2588048543A5014307727 @default.
- W2588048543 hasAuthorship W2588048543A5017521861 @default.
- W2588048543 hasAuthorship W2588048543A5022862706 @default.
- W2588048543 hasAuthorship W2588048543A5054609444 @default.
- W2588048543 hasAuthorship W2588048543A5055388143 @default.
- W2588048543 hasAuthorship W2588048543A5085617964 @default.
- W2588048543 hasBestOaLocation W25880485431 @default.
- W2588048543 hasConcept C104317684 @default.
- W2588048543 hasConcept C126322002 @default.
- W2588048543 hasConcept C134018914 @default.
- W2588048543 hasConcept C1491633281 @default.
- W2588048543 hasConcept C16224149 @default.
- W2588048543 hasConcept C17991360 @default.
- W2588048543 hasConcept C185592680 @default.
- W2588048543 hasConcept C202751555 @default.
- W2588048543 hasConcept C2776985958 @default.
- W2588048543 hasConcept C2777350992 @default.
- W2588048543 hasConcept C2777411675 @default.
- W2588048543 hasConcept C2777622882 @default.
- W2588048543 hasConcept C2778163477 @default.
- W2588048543 hasConcept C2778326061 @default.
- W2588048543 hasConcept C2780072125 @default.
- W2588048543 hasConcept C43554185 @default.
- W2588048543 hasConcept C519581460 @default.
- W2588048543 hasConcept C55493867 @default.
- W2588048543 hasConcept C71924100 @default.
- W2588048543 hasConcept C85789140 @default.
- W2588048543 hasConcept C86339819 @default.
- W2588048543 hasConcept C86803240 @default.
- W2588048543 hasConcept C95444343 @default.
- W2588048543 hasConceptScore W2588048543C104317684 @default.
- W2588048543 hasConceptScore W2588048543C126322002 @default.
- W2588048543 hasConceptScore W2588048543C134018914 @default.
- W2588048543 hasConceptScore W2588048543C1491633281 @default.
- W2588048543 hasConceptScore W2588048543C16224149 @default.
- W2588048543 hasConceptScore W2588048543C17991360 @default.
- W2588048543 hasConceptScore W2588048543C185592680 @default.
- W2588048543 hasConceptScore W2588048543C202751555 @default.